5-Amino-1MQ yog ib qho me me -molecule selective inhibitor, tsis yog peptide, thiab yog cov cuab yeej tshawb fawb nrov hauv thaj teb ntawm cov metabolism. Nrog nws cov hom phiaj zoo heev rau NNMT thiab tsis tshua muaj kev cuam tshuam ntawm lub hom phiaj, nws yog qhov tsim nyog rau kev txiav cov cellular methyl metabolism thiab lub zog homeostasis txoj hauv kev. Ntau pawg tshawb fawb siv cov khoom xyaw no thaum kawm adipocytes metabolism, NAD⁺ kev tswj hwm, thiab cov txheej txheem kev laus. Cov khoom no yog rau kev tshawb fawb hauv vitro nkaus xwb thiab txwv tsis pub siv rau tib neeg, kev kho mob, thiab kev zoo nkauj.
Lub luag haujlwm tseem ceeb:
Txhim kho Lipid Metabolism: Los ntawm inhibiting NNMT, nws txo qhov ntim ntawm cov adipocytes dawb thiab txhawb nqa lipid oxidation, txo cov rog uas tsis muaj kev tshaib plab.
Boosting Cellular Zog: Nce NAD + ntau ntau, txhim kho mitochondrial muaj nuj nqi, txhim khu lub cev endurance, thiab accelerates post- qoj ib ce rov qab.
Txhim kho Metabolism thiab Anti-Kev laus: Txhim kho cov tshuaj insulin, txo cov kab mob hauv lub cev, thiab txhawb nqa DNA kho, uas tuaj yeem ncua kev laus ntawm cellular.
Tsim nyog Scenarios
Ua ncaj ncees, yog tias koj tau sim ntau yam kev poob phaus tab sis raug daig ntawm toj siab, tshwj xeeb tshaj yog cov rog tawv tawv uas ua rau koj nce qhov hnyav txawm tias los ntawm kev haus dej, lossis yog tias koj nquag nkees thiab tsis muaj zog thiab tab tom nrhiav txoj hauv kev los txhawb cov metabolism hauv qib cellular, ces qhov no yog qhov kev xaiv zoo nkauj heev. Ntau tus neeg nyiam kev noj qab haus huv lossis tiv thaiv - cov neeg nyiam kev laus siv nws los kho lub cev. Txawm li cas los xij, peb yuav tsum paub meej: cov khoom no tseem tsis tau pom zoo los ntawm FDA, thiab feem ntau ntawm cov pov thawj los ntawm kev sim nas, tsis muaj cov ntaub ntawv kho mob tiag tiag ntawm tib neeg. Yog li, tam sim no nws yog ntau dua rau thaj tsam ntawm "txiav-ntug biohacking" kev tshawb nrhiav. Tsis txhob kho nws li panacea, thiab yeej tsis cia siab tias nws yuav hloov cov zaub mov noj qab haus huv thiab kev tawm dag zog.
Kev cia khoom
Txias- cov hmoov qhuav (qib tshawb fawb): -20 degree, tiv thaiv lub teeb, ruaj khov rau 12-24 lub hlis; 2-8 degree, luv luv cia rau ob peb lub lis piam. Cov molecules me me yog qhov ruaj khov dua li peptides, tab sis clumping tom qab nqus dej yuav cuam tshuam qhov hnyav. Desiccant suav nrog.
Cov tshuaj ntsiav ntawm qhov ncauj (cov khoom lag luam grey): Khaws rau hauv qhov chaw txias, qhuav qhov chaw deb ntawm lub teeb (15-25 degree). Tsis txhob tso rau hauv chav dej lossis ze ntawm lub qhov rais tsheb. Quaternary ammonium ntsev feem ntau tsis yooj yim degraded, tab sis lub capsule plhaub yuav ua nplaum yog damp.
Rov ua dua (siv subcutaneous): maj mam thawb cov dej tsis huv / dej physiological raws phab ntsa, maj mam yob, thiab siv li ntawm 7-14 hnub ntawm 2-8 degree, deb ntawm lub teeb. Tsis txhob khov-thaw cov tshuaj (txawm hais tias me me molecules tsis yooj yim puas los ntawm khov, rov khov dua-thaw cycles yuav ua rau crystal form hloov). Cov tshuaj tsis muaj xim thiab meej yog qhov qub; pov tseg yog tias huab.
Ntsuas qhov ntsuas qhov sib npaug thiab qhov qis -absorption raj; tsis txhob siv chav ua noj los ntsuas qhov "dawb".
Lus Cim: 5-amino-1MQ muaj cov qauv quaternary ammonium, yog dej-soluble, tab sis pH rhiab heev; tsis txhob siv cov acids uas muaj zog los yog cov hauv paus los kho cov kev kho dua tshiab.
Cov kev ceev faj:
Ncuav dej txias ua ntej: Cov molecule no yog ib qho piv txwv ntawm "cov ntaub ntawv zoo hauv cov nas, cov ntaub ntawv xoom hauv tib neeg, thiab lub hom phiaj tseem ceeb rau cov khoom lag luam grey". Sinclair's *Aging 2020* daim ntawv nthuav tawm cov ntaub ntawv ntawm 5-amino-1MQ hauv cov nas dhau 4-12 lub lis piam. Nws tsis tuaj yeem hais txog seb qhov no puas tuaj yeem rov ua dua rau tib neeg, lossis seb puas muaj kev cuam tshuam methylation mus sij hawm ntev yuav muaj kev cuam tshuam tsis zoo (NNMT nws tus kheej tau hais tawm hauv daim siab mob qog noj ntshav, thiab inhibiting nws tuaj yeem txhawb kev loj hlob hauv qee cov qauv qog-ib qho teeb meem tsis sib haum).
Qhov teeb meem loj tshaj plaws hauv kev lag luam grey no: cov ntsiab lus tiag tiag ntawm cov tshuaj 50mg tau thov, txawm tias nws yog tov nrog MNA nws tus kheej, thiab seb puas muaj cov khoom seem (quinolinamine intermediates yog tshuaj lom). Daim Ntawv Pov Thawj Kev Tso Cai (COA) feem ntau yog tus kheej - luam tawm. Yog tias koj yuav koom nrog, tsawg kawg yog nrhiav thib peb-cov ntaub ntawv tshaj tawm nrog HPLC/MS; tsis txhob ntseeg qhov "pharmaceutical grade" rhetoric.
Kev noj tshuaj yog tag nrho raws li kev hloov pauv ntawm tus nas (10 mg / kg hauv nas → kwv yees li 1.6 mg / kg subcutaneously hauv tib neeg, lossis 50-100 mg / hnub ntawm qhov ncauj raws li cov lus qhia hauv zej zog). Tsis muaj leej twg siv cov ntaub ntawv qhov rai kev nyab xeeb; lub sij hawm ntev - cuam tshuam ntawm daim siab methylation load thiab ntiaj teb SAM hloov pauv tsis paub.
Cov kev phiv tshwm sim: mob taub hau, xeev siab me ntsis, pw tsaug zog (SIRT1 cuam tshuam rau lub plawv dhia hauv qee tus neeg tom qab kev ua haujlwm NAD), qee zaus palpitations; Cov neeg uas muaj kab mob siab lossis methylation rhiab heev (MTHFR hloov pauv, qib homocysteine siab) yuav tsum tsis txhob sim qhov no, vim tias NNMT inhibition yuav cuam tshuam rau lub ntiaj teb SAM pas dej.
Zam zam thaum cev xeeb tub / pub niam mis, rau cov menyuam yaus, cov neeg muaj keeb kwm mob qog noj ntshav, lossis thaum lub sijhawm ua haujlwm autoimmune.
WADA nruj me ntsis tswj txoj cai no; zam lub cev tsim / txhawb nqa / triathlon.
Cim npe nrov: kub-muag siab- zoo peptide khoom 5-amino-1mq cas42464-96-0, Tuam Tshoj kub muag khoom zoo peptide khoom 5-amino-1mq cas42464-96-0 manufacturers, lwm tus neeg, Hoobkas
