Glutathione (GSH) yog ib qho tripeptide muaj li ntawm glutamic acid, cysteine, thiab glycine, dav nyob rau hauv yuav luag txhua tus tib neeg cell. Nws lub cev tseem ceeb ntawm lub cev yog nyob hauv cov pab pawg sulfhydryl uas muaj zog heev (-SH) ntawm cov cysteine residue. Cov pab pawg sulfhydryl no ua haujlwm zoo li "tus yuam sij thoob ntiaj teb," ncaj qha cuam tshuam cov dawb radicals hauv lub cev, koom nrog cov tshuaj tiv thaiv redox, thiab tswj cov cellular redox homeostasis. Nyob rau tib lub sijhawm, nws tuaj yeem khi rau cov co toxins xws li tshuaj thiab cov hlau hnyav hauv lub cev, hloov mus rau hauv cov khoom tsis zoo rau excretion los ntawm biotransformation. Tsis tas li ntawd, GSH tuaj yeem qhib ntau yam sulfhydryl enzymes, txhawb cov metabolism ntawm carbohydrates, rog, thiab cov proteins, ua haujlwm tseem ceeb ntawm kev sib txuas ntawm cellular metabolism thiab txoj hmoo ntawm tes.
Lub luag haujlwm tseem ceeb:
* **Antioxidant thiab Cell Protection:** Scavenes reactive oxygen hom, tiv thaiv cov proteins, lipids, thiab DNA los ntawm oxidative puas, thiab ncua cellular aging.
* ** Integrative Detoxification:** Ua raws li "scavenger" rau daim siab, pab kho lub siab puas tsuaj los ntawm cawv, tshuaj, thiab tshuaj.
* ** Tswj Kev Tiv Thaiv thiab Metabolism: ** Txhawb nqa lub cev tiv thaiv kab mob ua haujlwm thiab koom nrog hauv lub zog metabolism raws li coenzyme.
Siv tau Scenarios
Kab mob siab Adjuvant Therapy: Rau lub siab puas tsuaj los ntawm cov kab mob / cawv / yeeb tshuaj / tsis yog- kab mob siab ua rau lub siab muaj dej cawv, tso rau hauv 1.2-1.8 g / hnub yog cov tshuaj niaj hnub hauv tsev kho mob adjuvant; qhov ncauj 400 mg peb-hnub (tid) yog siv rau kev tiv thaiv daim siab hauv kab mob siab B (cov ntsiav tshuaj thiab txhaj tshuaj muaj nyob hauv Suav teb);
Tshuaj khomob/xov tooj cua tiv thaiv: 1.5 g/m² intravenously 15 feeb ua ntej siab - koob tshuaj chemotherapy kom txo cisplatin nephrotoxicity, cyclophosphamide cystotoxicity, thiab radiotherapy mucosal puas;
Poisoning Rescue Adjuvant Therapy: Adjuvant therapy for acetaminophen overdose (NAC yog qhov tseem ceeb, tab sis GSH ua haujlwm ntawm tib txoj cai), organophosphates, thiab hnyav hlau raug;
Hypoxemia / ARDS / Sepsis: Raws li kev txhawb nqa redox, tsis yog cov tshuaj thawj zaug;
Ophthalmology: Glutathione qhov muag tee yog siv rau cov kab mob cataracts thaum ntxov, corneal ulcers, thiab keratitis (kev lag luam muaj cov qauv tsim muaj);
Whitening/Anti-Photoaging: Qhov ncauj 250–500 mg/hnub tau qhia melanin Performance index thiab L* hauv me me RCTs. Tus nqi nce me ntsis, tab sis cov nyhuv me me thiab sib txawv heev ntawm ib tus neeg mus rau lwm tus; tshuaj pleev 2% oxidative cream tau pom kev txhim kho nyob rau hauv UV erythema, thaum venous whitening yog off- daim ntawv lo thiab tsis muaj siab -RCTs zoo, thiab Philippine FDA tau tshaj tawm lus ceeb toom tshwj xeeb;
Kev tshawb fawb qib: cell redox lub xeev sojntsuam, cryoprotectant, thiol siv hauv peptide synthesis.
Kev cia khoom
Pharmaceutical Preparations (Lyophilized for Injection): Khaws rau hauv nws qhov qub ntim ntim rau hauv qhov chaw txias, tsaus nti (tsis pub tshaj 20 degree), tiv thaiv lub teeb thiab kom qhuav. Tsis txhob khov (txias lub ncuav mog qab zib lyophilized nws tus kheej yog qhov zoo, tab sis tsis txhob rov khov dua -thaw cycles). Cov tsev muag tshuaj hauv tsev kho mob feem ntau khaws cia rau hauv lub teeb -cov txee tiv thaiv ntawm 2–8℃. Tom qab dissolving, siv li ntawm 2 teev nyob rau hauv chav tsev kub, los yog tsis pub tshaj 8 teev ntawm 0-5 degree. Tshem tawm cov kua uas seem.
Kev tshawb fawb- Qib Txo GSH Powder: tuaj yeem khaws cia rau 1-2 xyoos ntawm 2-8 degree, tiv thaiv lub teeb thiab noo noo. Nws ruaj khov dua ntawm -20℃. Nws cov tshuaj aqueous oxidizes thiab tig daj thaum raug huab cua. Rau kev kho dua tshiab, nws raug pom zoo kom siv cov pa oxygen{14}} dej dawb / dej tsis muaj zog acidic (pH 6.5-7.5 yog qhov ruaj khov tshaj plaws). Npaj thiab siv tam sim ntawd. Yog tias koj yuav tsum khaws cia, aliquot rau hauv ib qho kev siv, khaws cia hauv nitrogen ntawm -20 degree, thiab siv hauv ib hlis.
Cov tshuaj tsis muaj xim thiab meej yog qhov qub. Yog tias nws hloov daj daj → daj → xim av, nws qhia tias GSH tau hloov mus rau GSSG thiab re-agglomerated; tsis txhob siv cov tshuaj no.
Ntsiav tshuaj / Capsules: Khaws rau hauv qhov chaw txias, qhuav qhov chaw tiv thaiv los ntawm lub teeb. Tsis txhob tso rau hauv chav dej.
Cov kev ceev faj
Cov khoom no yog ib qho ntawm feem ntau "tag nrho- muaj zog" antioxidants ntim rau hauv kev lag luam ntxiv kev noj qab haus huv- muab cov pob ua tiav ntawm "detoxification, whitening, anti-aging, siab tiv thaiv, thiab kho-tag nrho." Txawm li cas los xij, nws lub qhov ncauj bioavailability yog qhov tsawg heev (vim plab hnyuv peptide enzyme digestion thiab ua ntej - dhau cov metabolism hauv lub siab, qhov nce hauv GSH dawb hauv cov ntshav yog txwv; lub cev feem ntau tso siab rau kev ntxiv NAC / cysteine / glycine los tsim nws tus kheej). Kev txhaj tshuaj yog tib txoj kev uas nws nkag mus rau hauv cov hlab ntsha tiag tiag. Txawm li cas los xij, kev txhaj tshuaj rau kev ntxuav hniav dawb yog ib qho kev tshem tawm - kev kho daim ntawv lo, thiab cov xwm txheej ntawm kev tsis haum tshuaj thiab kev poob siab tau tshwm sim.
Kev txhaj tshuaj GSH tuaj yeem ua rau anaphylactic poob siab. Cov neeg uas muaj keeb kwm mob hawb pob lossis ua xua yuav tsum tsis txhob txhaj tshuaj rau sab nraud ntawm lub tsev kho mob, thiab txawm tias tsev kho mob yuav tsum muaj cov chaw kho mob txaus. Txiav tawm tam sim ntawd yog tias pob khaus, hauv siab nruj, hawb pob, lossis ntshav siab tshwm sim.
Tsis txhob sib xyaw nrog Vitamin B12, K3, calcium pantothenate, sulfonamides, tetracyclines, lossis tshuaj tiv thaiv kab mob, vim qhov no yuav ua rau nag lossis daus los ntawm kev ua haujlwm.
Kev tswj qhov ncauj feem ntau yog ua tau zoo- zam, nrog qee zaus xeev siab thiab tsis xis nyob hauv plab. Thaum lub sij hawm ntev - lub sij hawm, siab - koob tshuaj tib neeg cov ntaub ntawv kev nyab xeeb yog txwv, niaj hnub kev tswj hwm ntawm ntau pua milligrams feem ntau tsis yog qhov ua rau muaj kev txhawj xeeb.
Rau cov poj niam cev xeeb tub, niam pub niam mis, menyuam yaus, thiab cov neeg ua pa hnyav / lub raum tsis ua haujlwm, txoj kev txhaj tshuaj yuav tsum raug txiav txim los ntawm kws kho mob. Tsis txhob yuav cov hmoov lyophilized thiab sib tov nrog lub syringe koj tus kheej.
Rau cov tawv nqaij dawb, tshuaj pleev thaiv hnub + Vitamin C + niacinamide + kev pw tsaug zog tsis tu ncua yog tus nqi ntau dua - zoo tshaj qhov ncauj GSH. Intravenous GSH rau whitening lag luam kev ua xua thiab tus nqi siab dua rau "tej zaum me ntsis ntawm daim tawv nqaij dawb."
Cim npe nrov: siab -kev tshawb fawb zoo-qib peptide glutathione cas 70-18-8., Tuam Tshoj high-quality research-qib peptide glutathione cas 70-18-8. manufacturers, lwm tus neeg, Hoobkas
