GLP-1 yog 30-amino acid incretin hormone secreted los ntawm txoj hnyuv L hlwb tom qab noj mov, nrog rau qhov hnyav molecular ntawm kwv yees li 3.3 kDa. Nws N-terminal thib ob histidine (His⁷) yog qhov chaw cleavage rau DPP-4, ua rau ib nrab-lub neej luv heev rau endogenous GLP-1 hauv plasma-nws yog cleaved rau hauv inactive GLP-1(9-36) metabolites nyob rau hauv tsawg dua 2 feeb.
Core Physical Mechanism:
Cov txheej txheem tseem ceeb ntawm GLP-1 yog receptor tshwj xeeb ua kom ua ke nrog cov kev cai hauv qab dej metabolic. Nws cov qauv luv luv, nrawm nrawm, thiab cov lus teb rhiab heev ua rau nws muaj kev hloov pauv hloov pauv peptide.
Nws tshwj xeeb lees paub thiab khi rau ntawm lub xov tooj ntawm tes GLP-1R receptor, ua kom lub cAMP signaling cascade los tswj intracellular calcium homeostasis thiab kev qhia ntawm cov protein metabolic tseem ceeb, zoo kho cov piam thaj metabolism hauv cov teeb liab cuam tshuam. Hauv qib cellular, nws tuaj yeem txhim kho cellular metabolic ntshawv siab nyob rau hauv qabzib kev nyuaj siab, txhim kho cellular metabolic kam rau ua, thiab inhibit qhov kev qhia ntawm txawv txav metabolic yam.
Tsis zoo li ntev - ua yeeb yam hloov pauv peptides, haiv neeg GLP-1 muaj lub sijhawm luv luv ntawm kev ua thiab kev tswj tau cov metabolic hauv lub cev, zam kev ua kom tsis muaj zog. Qhov no ua rau nws zoo tagnrho rau kev kawm "physiological metabolic regulation" es tsis yog cov teebmeem ntawm kev siv tshuaj muaj zog, uas yog vim li cas nws yog qhov kev xaiv zoo tshaj plaws rau kev tshawb fawb hauv paus.
Muaj feem xyuam rau Kev Tshawb Fawb Scenarios
Tam sim no, kev sim cov lus qhia rau GLP-1 ntawm kev ua lag luam yog cov concentrated, feem ntau poob rau hauv cov pawg hauv qab no:
- Glucose metabolism, insulin tsis kam, thiab pancreatic islet cell functions -txog cov txheej txheem
- Cov tshuaj hormones plab hnyuv, plab axis signaling, thiab kev sim tshuaj endocrine
- Cellular zog metabolism, lipid deposition, thiab metabolic stress model kev tshawb fawb
- GLP-1 receptor activation, protein binding, thiab txoj kev taug kev nce toj thiab nqes dej validation thwmsim
- Kev tshuaj xyuas hauv vitro thiab tswj kev ua qauv ntawm cov tshuaj tshiab metabolic lead
- Kev tshawb xyuas ntawm cov kab mob metabolic, microenvironment homeostasis, thiab cov txheej txheem kho cell
Kev cia khoom
Marketed formulations (pens/pre{0}}filled syringes):
Tsis qhib: Txias ntawm 2-8 degree, tiv thaiv los ntawm lub teeb. Kev khov yog nruj me ntsis txwv tsis pub (txias yuav denature proteins, thiab txawm tias thawing yuav ua rau cov khoom siv tsis tau). Khaws nyob rau hauv lub rear compartment ntawm lub tub yees, tsis nyob rau ntawm lub qhov rooj txee (vim kub hloov pauv loj).
Qhib / siv tam sim no cwjmem: Khaws ntawm chav tsev kub tsawg dua lossis sib npaug li 30 degree, tiv thaiv lub teeb, rau 4-6 lub lis piam (saib cov lus qhia tshwj xeeb, piv txwv li, Ozempic 56 hnub tom qab qhib, Mounjaro 21 hnub tom qab qhib). (Siv hauv 1 hnub) Muab pov tseg yog tias tas sij hawm; tsis txhob tso tub yees ntau zaus.
Thaum tshem tawm: Khaws rau hauv qhov ntim thawj ntawm tsawg dua lossis sib npaug li 30 degree, deb ntawm lub teeb thiab ncaj qha tshav ntuj. Thaum lub caij ntuj sov, siv ib lub hnab insulated nrog cov khoom khov nab kuab (tsis txhob kov cov cwj mem ncaj qha).
Kev tshawb fawb- qib lyophilized hmoov (piv txwv li, ntshiab GLP-1 peptide):
Lyophilized ncuav mog qab zib: qhuav ntawm -20℃deb ntawm lub teeb; ruaj khov rau ntau tshaj 24 lub hlis; ntawm 2-8℃rau lub sijhawm luv luv ntawm ob peb lub lis piam.
Kev kho dua tshiab: Siv tsis muaj PBS (pH 7.4) lossis cov kua qaub tsis muaj zog (kom tiv thaiv kev sib sau), maj mam thawb rau ntawm phab ntsa, ntawm 2-8℃deb ntawm lub teeb, siv li ntawm 7-14 hnub. Tsis txhob khov -thaw cov tshuaj (khov-thaw yuav rhuav tshem cov qauv -helix).
Cov tshuaj yuav tsum yog ntshiab thiab tsis muaj xim. Muab pov tseg tam sim yog muaj huab, tsis muaj xim (xws li, daj), lossis muaj cov teeb meem tshem tawm.
Cov kev ceev faj
Ua ntej thiab qhov tseem ceeb tshaj plaws: GLP-1 tsis yog "qhov hnyav tshaj plaws -cov tshuaj poob," tab sis yog "tus tswj cov metabolism." Tam sim no nws tau raug tshaj tawm hauv online raws li "kev kho txuj ci tseem ceeb rau kev poob phaus thaum pw," ua rau ntau tus poj niam noj qab haus huv nrog BMI ntawm 22 kom ua raws li kev coj ua. Qhov no yog qhov tsis ncaj ncees lawm - nws cov neeg tau txais txiaj ntsig yog cov neeg mob ntshav qab zib thiab cov neeg rog rog uas muaj teeb meem metabolic, tsis yog cov tib neeg uas xav hnav qhov loj S.
Cov kev mob tshwm sim tsis tuaj yeem zam: xeev siab, ntuav, raws plab, cem quav, thiab tsam plab, tshwj xeeb tshaj yog nyob rau ob lub lis piam ntawm kev noj tshuaj ntau ntxiv; Qee tus neeg txawm ntuav mus rau lub cev qhuav dej. Kev tswj hwm: Pib nrog ib koob tshuaj tsawg (piv txwv li, maj mam nce nrog 0.25mg / lub lis piam), noj me me, noj zaub mov tsis tu ncua, ua raws li kev noj zaub mov tsawg - rog, tsis txhob sim tawv nws tawm, thiab txo qhov ntau npaum li cas los yog nres yog ntuav hnyav.
Ceev faj ntawm tus mob pancreatitis: Txawm hais tias RCTs loj tsis tau lees paub tias muaj kev pheej hmoo ntau ntxiv, cov neeg muaj keeb kwm ntawm pancreatitis lossis hypertriglyceridemia yuav tsum siv ceev faj. Yog hais tias tsis tu ncua, mob plab sab sauv loj (rov qab mus rau sab nraub qaum) tshwm sim, tsis txhob noj cov tshuaj tam sim ntawd thiab nrhiav kev kho mob.
Cov teeb meem ntawm lub gallbladder: Qhov kev pheej hmoo ntawm cov roj cholesterol crystallization thiab cholecystitis yog nce me ntsis, tshwj xeeb tshaj yog rau cov neeg uas xav kom poob phaus sai. Tsis txhob tsis quav ntsej qhov mob plab sab sauv.
Thyroid C-cov qog nqaij hlav: Cov koob tshuaj ntau tau pom tias ua rau medullary thyroid carcinoma (MTC) hauv kev tshawb fawb tsiaj. Txawm hais tias tsis muaj pov thawj hauv tib neeg, FDA tau tshaj tawm lub thawv dub ceeb toom: MTC yog contraindicated nyob rau hauv cov neeg mob uas muaj tus kheej / tsev neeg keeb kwm ntawm tus kab mob los yog cov txiv neej 2. Cov thyroid ultrasound thiab calcitonin kuaj yuav tsum tau ua ntej noj tshuaj.
Muscle loss: Rapid weight loss (especially >5% ib hlis) yog nrog los ntawm lean loj poob. Cov neeg laus yuav tsum ceev faj ntawm sarcopenia; Kev cob qhia kev tiv thaiv thiab kev noj zaub mov muaj protein ntau yog qhov tseem ceeb heev.
Kev txo koob tshuaj thaum siv cov tshuaj hypoglycemic ib txhij: Thaum siv nrog sulfonylureas lossis insulin, tom kawg yuav tsum raug txo los ntawm 20-30%, txwv tsis pub txoj kev pheej hmoo ntawm hypoglycemia yuav nce siab.
Preoperative discontinuation ntawm cov tshuaj: Txiav tshuaj tsawg kawg ib lub lis piam ua ntej tshuaj loog / sib sib zog nqus sedation (vim lub plab zom mov qeeb thiab pheej hmoo ntawm aspiration). Qhia rau tus kws tshuaj loog tias koj siv GLP-1RA.
Cim npe nrov: cov chaw tsim khoom zoo tshaj plaws - muag peptide freeze- cov hmoov qhuav, glp-1, cas 87805-34-3, Tuam Tshoj cov chaw tsim khoom zoo tshaj plaws muag peptide khov-qhuav hmoov, glp-1, cas 87805-34-3 manufacturers, lwm tus neeg, Hoobkas
