Kisspeptin yog ib qho protein ntau tshwm sim hauv tib neeg lub cev uas ua lub luag haujlwm tseem ceeb hauv kev qhia cov tshuaj hormones, tshwj xeeb tshaj yog thaum puberty thiab kev loj hlob. Txoj kev loj hlob ntawm Kisspeptin-10 lub hom phiaj ua kom zoo li kev ua haujlwm ntawm Kisspeptin hauv lub cev. Ntxiv rau nws lub luag haujlwm ntawm kev yug me nyuam, Kisspeptin tau pom tias muaj kev cuam tshuam rau tus cwj pwm thiab kev xav, thiab txawm tswj lub raum ua haujlwm.
Kisspeptin-10 yog dab tsi?
Kisspeptin-10 yog ntu luv thiab muaj zog tshaj plaws ntawm Kisspeptin protein, encoded los ntawm KISS1 noob. Tshawb nrhiav hauv Hershey, Pennsylvania (li no lub npe "Hershey's Kiss" chocolate), nws tau pib xav tias muaj kev cuam tshuam rau kev mob qog noj ntshav. Txawm li cas los xij, nws txoj haujlwm tseem ceeb tshaj plaws tom qab tau tshawb pom los ua tus tswj hwm ntawm hypothalamic-pituitary-gonadal axis (HPG axis)-lub hauv paus tswj kev tso tawm ntawm cov tshuaj hormones kev loj hlob.
Qhov tseem ceeb, Kisspeptin-10 yog qhov tseem ceeb rau kev pib tso tawm ntawm gonadotropin- tso cov tshuaj hormone (GnRH). Nws ua rau cov neurons tshwj xeeb hauv hypothalamus, ua rau pulsatile tso tawm GnRH. Qhov no, nyob rau hauv lem, taw qhia lub caj pas pituitary tso tawm ob yam tshuaj hormones tseem ceeb: luteinizing hormone (LH) thiab follicle-stimulating hormone (FSH). Qhov no cascade yog ib qho tseem ceeb rau cov txiv neej ncaws pob vim hais tias LH qhia tshwj xeeb rau cov hlwb interstitial nyob rau hauv cov qe ntshav los tsim thiab tso testosterone.
Nws yog ib qho tseem ceeb kom paub meej tias Kisspeptin-10 tsis yog anabolic steroid; nws tsis muaj qhov ncaj qha mechanism rau kev txhawb cov leeg nqaij. Nws qhov kev txiav txim yog tsis ncaj ncees lawm, muaj zog txhawb lub cev tus kheej endogenous testosterone ntau lawm.
Cov txiaj ntsig tseem ceeb ntawm High -Kisspeptin Zoo
Kisspeptin yog ib qho tshiab, muaj zog heev qhia peptide uas nws cov khoom tau ua rau nws ua kom pom tseeb ntawm kev tshawb fawb thiab kev tsim tshuaj.
1. Siab Bioactivity thiab Targeting
Kisspeptin muaj kev sib raug zoo siab heev rau KISS1R receptor thiab yog ib qho muaj zog tshaj plaws paub GnRH secretion stimulants, ua lub luag haujlwm tseem ceeb hauv kev tswj cov kev ua me nyuam axis.
2. Natural Source thiab Well-Defined Structure
Kisspeptin yog muab los ntawm cov biomolecule endogenous, ua rau nws yooj yim dua rau lub cev kom paub thiab metabolize, thiab muaj kev ruaj ntseg zoo.
3. Kev koom tes dav thoob plaws ntau lub tshuab
Nws qhov kev tshawb fawb tus nqi npog ntau qhov chaw:
Tshuaj Kho Mob
Hormonal Regulation nyob rau hauv thaum yau thiab Adulthood
Tumor Metastasis Related Research
Zog Metabolism Balance thiab Obesity Mechanisms
Cov kab mob plawv thiab kev xav cwj pwm
4. Yooj yim ntawm Peptide Engineering
C-terminal sequence yog ib qho tseem ceeb khaws cia tawg; Yog li ntawd, kev ruaj ntseg thiab ib nrab-Lub neej ntawm Kisspeptin tuaj yeem txhim kho tau yooj yim thiab ntev los ntawm kev hloov pauv amino acid, kev hloov pauv, thiab kev hloov kho lipid, muab chav rau kev tsim kho.
3. Cov lus piav qhia ntxaws txog Physicochemical Properties
Raws li peptide raw khoom, Kisspeptin muaj ib tug series ntawm physicochemical zog:
1. Molecular Structure
Tsim los ntawm ntau cov amino acids txuas los ntawm peptide bonds.
C-terminal sequence yog qhov tseem ceeb hauv cheeb tsam.
Muaj cov isoforms sib txawv (piv txwv li, 10, 13, 14, thiab 54 amino acids).
1. **N-terminal lossis C-terminal modification los txhim kho kev ruaj ntseg:** N-terminal lossis C-terminal modification tuaj yeem ua raws li qhov xav tau.
2. ** Molecular Nyhav Range:**
Kisspeptin-10: Kwv yees li 1300-1500 Daltons
Kisspeptin-14: Kwv yees li 1700–1800 Daltons
Kisspeptin-54: Kwv yees li 6000–7000 Daltons
Qhov hnyav molecular sib txawv ua rau muaj qhov sib txawv me me hauv kev ruaj ntseg, metabolic tus nqi, thiab receptor ua kom muaj peev xwm.
3. ** Solubility: **
Nquag soluble hauv dej thiab dilute acidic buffer daws.
Kuj tseem soluble nyob rau hauv ntau lub cev tsis zoo xws li PBS thiab HEPES.
Kub rhiab heev; qis - qhov kub thiab txias cia yog pom zoo.
4. ** Kev ruaj ntseg: **
Cov hmoov lyophilized pom zoo stability.
Yuav khaws tau ntev -lub sij hawm tiv thaiv los ntawm lub teeb ntawm qhov kub thiab txias (-20℃lossis qis dua).
Vim hais tias cov peptide chains yog nquag hydrolysis los yog oxidation, nws yuav tsum tau siv nyob rau hauv cov tshuaj rau lub sij hawm luv luv.
5. Charge Properties thiab Isoelectric Point
Feem ntau weakly acidic.
Qhov taw tes isoelectric feem ntau yog nruab nrab ntawm pH 5 thiab 7.
Pom zoo receptor binding kev ua si nyob rau hauv physiological pH tej yam kev mob.
Yuav Order li cas?
Ua ntej, thov qhia peb txog koj qhov kev xav tau lossis daim ntawv thov scenario.
Thib ob, peb yuav muab cov lus hais raws li koj qhov xav tau lossis peb cov lus qhia.
Thib peb, tus neeg siv khoom lees paub cov qauv thiab them tus nqi tso nyiaj.
Plaub, peb muaj lub luag haujlwm rau kev npaj ntau lawm. Cov luv nqi muaj rau kev txiav txim ntau.
Koj cov khoom zoo li cas? Ua ntej, peb cov khoom zoo heev thiab ruaj khov zoo. Peb ua 100% kuaj ua ntej xa zaub mov.
Yog li ntawd, peb ua nruj tswj xyuas ua ntej ua zaub mov xa tuaj. Yog tias muaj teeb meem zoo tau pom los ntawm peb, peb yuav hloov cov khoom dawb los yog muab cov nyiaj rov qab.
Yuav Ua Li Cas Tsim Ib Lub Sijhawm Ntev -, Kev Koom Tes Zoo Nrog Peb?
1. Peb hais kom muab siab - cov khoom zoo thiab cov nqi sib tw kom ntseeg tau cov neeg siv khoom zoo;
2. Peb hwm txhua tus neeg siv khoom, saib lawv li phooj ywg, thiab ua siab dawb ua lag luam thiab ua phooj ywg nrog lawv, txawm lawv tuaj qhov twg los.
Cim npe nrov: Kev tshawb fawb- cov tshuaj peptide tshwj xeeb Kisspeptin 10mg / vial, Tuam Tshoj Kev Tshawb Fawb -cov tshuaj peptide tshwj xeeb Kisspeptin 10mg / vial manufacturers, lwm tus neeg, Hoobkas
