Kev piav qhia
IGF-DES (tseem hu ua IGF-1 DES, DES(1-3)IGF-1) yog luv luv peptide daim ntawv ntawm insulin-zoo li kev loj hlob. Nws cov qauv yog 67-amino acid peptide tsim los ntawm truncating thawj peb amino acids los ntawm N-terminus ntawm lub ntuj tib neeg IGF-1 molecule. Vim yog cov qauv luv luv no, IGF-DES nthuav tawm cov khoom sib txawv ntawm tus qauv IGF-1 hauv cov ntsiab lus ntawm molecular conformation, receptor affinity, kev ua hauv zos, thiab cov ntaub so ntswg faib. IGF-DES tau pib siv feem ntau rau kev tshawb fawb, xws li kev kawm cov ntaub so ntswg hauv zos ntawm IGF-1, cov qauv kev loj hlob ntawm tes, kev tshawb fawb txog kev qhia, thiab kev tshawb fawb txog metabolic. Raws li cov khoom siv peptide muaj zog heev, nws maj mam tau txais txoj haujlwm tseem ceeb hauv kev tshawb fawb qib kev lag luam.
Qhov sib txawv tseem ceeb ntawm IGF-1:
● Cov qauv yooj yim: luv peptide saw (70 amino acids vs . 73 amino acids).
● Protein- ywj siab: Nws siv nws cov txiaj ntsig yam tsis muaj IGFBP kev sib kho.
● Qhov chaw- tshwj xeeb ua: Ua kom muaj txiaj ntsig hauv zos tom qab txhaj tshuaj intramuscular.
IGF -DES(1-3) yog dab tsi?
IGF-DES (1-3) yog ib qho kev sib xyaw ua ke ntawm cov tshuaj insulin zoo li kev loj hlob 1 (IGF-1). Txhawm rau nkag siab DES, ib tus yuav tsum nkag siab IGF-1 ua ntej. IGF-1 yog ib yam tshuaj hormones feem ntau tsim nyob rau hauv lub siab nyob rau hauv teb rau stimulation los ntawm kev loj hlob hormone (GH). Nws yog tus neeg nruab nrab tseem ceeb ntawm GH anabolic metabolism (cov leeg nqaij loj hlob), ua lub luag haujlwm tseem ceeb hauv kev loj hlob ntawm menyuam yaus thiab kev loj hlob thiab txuas ntxiv ua rau cov teebmeem anabolic hauv cov laus.
Ib txwm tam sim no IGF-1 yuav luag ib txwm khi rau ib qho ntawm ob peb IGF-binding proteins (IGFBPs). Cov binding proteins no ua kom ntev ib nrab ntawm lub neej ntawm IGF-1 hauv cov ntshav, los ntawm feeb mus rau teev. Txawm li cas los xij, qhov kev khi no tseem cuam tshuam nws cov kev ua haujlwm lom neeg vim tias cov protein ntau dhau los tawm hauv capillaries thiab cuam tshuam nrog cov leeg nqaij thiab cov rog.
Qhov no yog qhov sib txawv ntawm IGF-DES thiab IGF-DES. "DES" sawv cev rau "Des(1-3)", qhia tias thawj peb cov amino acids ntawm IGF-1 saw tau raug tshem tawm. Qhov kev hloov pauv me me no muaj qhov cuam tshuam loj heev:
● Kev txo qis kev sib raug zoo ntawm kev sib raug zoo: DES hloov kho txo qhov kev sib raug zoo ntawm peptide rau IGFBP.
● Txhim kho potency: Unbound "dawb" IGF-DES nthuav tawm ntau dua affinity rau IGF-1 receptor (IGF-1R) ntawm lub hom phiaj hlwb-reportedly 5 mus rau 10 npaug ntau dua li haiv neeg IGF-1.
● Kev nqis tes ua hauv zos: Vim tias nws tsis tas yuav tsum tau khi cov proteins kom xa mus rau hauv cov hlab ntsha, cov haujlwm ntawm IGF-DES feem ntau txwv rau qhov chaw tswj hwm. Nws tsuas yog ua rau cov leeg mob tshwj xeeb txhaj tshuaj, nrog me me ntawm cov kab mob sib kis.
2 mg vials yog ib hom ntim ntim ntau, muaj cov hmoov lyophilized uas yuav tsum tau rov ua dua nrog cov dej tshuaj tua kab mob ua ntej siv.
Kev Tswjhwm Zoo thiab Kev Ntsuas Cov Qauv
Txhawm rau kom ntseeg tau qhov zoo ntawm kev tshawb fawb-qib IGF-DES, yuav tsum tau kuaj xyuas kom zoo, suav nrog:
1. Kev tsom xam Purity
Mainstream Analytical Methods:
Siab -Kev Ua Haujlwm Liquid Chromatography (HPLC)
Liquid Chromatography-Mass Spectrometry (LC-MS)
MALDI-TOF Mass Spectrometry
High- cov khoom zoo feem ntau xav tau tus qauv purity Ntau dua lossis sib npaug li 98%.
2. Molecular Weight Confirmation
Mass spectrometry tsom xam yog siv los xyuas kom meej tias qhov hnyav molecular phim tus nqi theoretical, zam impurities xws li truncated peptides thiab oxidized peptides.
3. Bioactivity-Txoj Kev Ntsuam Xyuas (Kev Tshawb Fawb Kev Tshawb Fawb)
Xws li:
IGF-1R Binding Capacity Assessment
PI3K/Akt Pathway Regulatory Strength Assessment
Cell Viability thiab Proliferation Assay
Cov kev ntsuas no yog rau kev tshawb fawb nkaus xwb thiab tsis tuaj yeem siv rau txhua daim ntawv thov kho mob.
4. Kev kuaj xyuas Endotoxin
High-zoo IGF-DES yuav tsum xeem dhau cov kev xeem hauv qab no:
Limulus Amebocyte Lysate (LAL) kev soj ntsuam txhawm rau txheeb xyuas cov qib endotoxin
Xyuas kom ua raws li kev tshawb fawb - qib lossis cov qauv tsis muaj menyuam
Cov txiaj ntsig tseem ceeb ntawm IGF-DES
Los ntawm kev tshawb fawb pom, IGF-DES muaj cov yam ntxwv tseem ceeb hauv qab no:
1. Muaj Kev Ua Si Hauv Zos
Vim muaj qhov txo qis kev sib khi rau IGFBP, IGF-DES muaj qhov siab dua qhov siab dua hauv cov ntaub so ntswg hauv zos, ua kom yooj yim rau khi rau IGF-1R thiab ua rau cov teeb liab hloov pauv.
2. Kev ua kom muaj teeb meem ceev dua
Tom qab khi rau nws cov receptor, IGF-DES tuaj yeem qhib:
PI3K/Akt txoj kev
MAPK/ERK txoj kev
Cov no feem ntau siv txoj hauv kev los kawm txog kev loj hlob ntawm tes, sib txawv, kho, thiab metabolism.
3. Cov ntaub so ntswg muaj zog
Piv rau qhov tsis zoo IGF-1, nws cov molecule luv thiab curvature ntau dua muab nws permeability ntau dua.
4. Muaj feem xyuam rau ntau yam kev tshawb fawb qauv
Xws li:
Kev sim ua kom loj hlob ntawm tes
Cov ntaub so ntswg regeneration qauv
Kev tshawb nrhiav metabolic
Growth factor kinetic tsom xam
Kev txhawb zog hauv zos-cov qauv muaj feem xyuam
5. Yooj yim khov- kom qhuav thiab khaws cia cov ntaub ntawv raw
Cov qauv ruaj khov, khov - ziab kom yooj yim ntev - lub sij hawm cia.
Peb Qhov Zoo
1. Zoo: Txhua yam khoom tau dhau los ntawm peb cov kws tshaj lij thiab tau lees paub ISO.
2. Nqe: Raws li lub Hoobkas, peb cov nqi qis dua li peb cov neeg sib tw. Cov luv nqi muaj rau kev txiav txim ntau.
3. Shipping: Peb muaj cov Tshuag txaus thiab tuaj yeem xa tuaj hauv 24 teev tom qab them nyiaj.
4. Kev xa rov qab txoj cai kom ua kom cov neeg siv khoom tau txais txiaj ntsig zoo tshaj plaws thiab txo qhov kev poob qis.
5. Zoo heev tom qab- kev muag khoom: Peb taug qab koj cov xwm txheej pob kom txog thaum xa khoom thiab ua txhua yam los daws cov teeb meem uas koj ntsib.
Cim npe nrov: Kev tshawb fawb-cov tshuaj peptide tshwj xeeb IGF-DES 2mg/vial, Tuam Tshoj Kev Tshawb Fawb-cov tshuaj peptide tshwj xeeb IGF-DES 2mg/vial manufacturers, lwm tus neeg, Hoobkas
