Liraglutide yog ntau yam thiab muaj txiaj ntsig zoo rau kev kho mob peptide siv los tswj ntshav qab zib, txhawb kev poob phaus, thiab txhim kho tag nrho cov hlab plawv thiab kev noj qab haus huv metabolic. Nws zoo txhim kho ntau yam ntawm metabolic syndrome, ua rau nws yog lub hauv paus ntawm cov tshuaj niaj hnub. Thaum siv kom raug thiab ua ke nrog kev hloov pauv hauv kev ua neej, liraglutide tuaj yeem xa cov txiaj ntsig ntev thiab hloov pauv, qhia txog nws cov txiaj ntsig raws li cov tshuaj tawg.
Liraglutide yog dab tsi?
Liraglutide yog GLP-1 analogues uas ua raws li qhov kev txiav txim ntawm lub cev tus kheej incretin. Nws txhim kho cov piam thaj-dependant insulin secretion, inhibits glucagon tso tawm, thiab ua rau lub plab khoob. Cov txheej txheem no ua haujlwm ua ke los tswj cov ntshav qab zib, txo qis qab los noj mov, thiab pab tswj qhov hnyav.
Tshuaj muaj pes tsawg leeg
● Molecular Formula: C172H265N43O51
● Molecular Luj: 3751.2 g/mol
● CAS Nr .: 204656-20-2
Ntsiab nta
● Hloov kho kom tau txais txiaj ntsig ntxiv, ib zaug - noj txhua hnub.
● Nws qhia txog 97% homology nrog tib neeg endogenous GLP-1.
● Nws tiv thaiv enzymatic degradation los ntawm dipeptidyl peptidase-4 (DPP-4).
Liraglutide sib txawv los ntawm cov tshuaj kho lub cev ib txwm muaj raws li hauv qab no:
1. Neurogenic Appetite Suppression: Tsis zoo li stimulant qab los noj mov suppressants (xws li caffeine thiab clenbuterol), liraglutide lub mechanism ntawm kev txiav txim yog lub hauv paus. Nws ncaj qha activates GLP-1 receptors nyob rau hauv lub hypothalamus, tshwj xeeb tshaj yog nyob rau hauv cov cheeb tsam uas tswj qab los noj mov thiab calorie ntau ntau. Qhov no ua rau muaj kev xav tau ntev thiab muaj txiaj ntsig zoo ntawm kev ua kom puv thiab txo "zais zaub mov" (piv txwv li, kev mob siab rau kev mob siab rau zaub mov thaum noj calorie tsis txaus). Qhov no yog nws cov khoom muaj nqis tshaj plaws rau bodybuilders.
2. Ncua Ncua Nroj Tsuag: Liraglutide prolongs postprandial satiety los ntawm qeeb tus nqi ntawm cov zaub mov tawm hauv plab thiab nkag mus rau hauv cov hnyuv. Cov nyhuv mechanical no ua tiav nws qhov kev ua haujlwm neural, ua kom yooj yim rau cov neeg mob kom ua raws li cov calories tsawg heev.
3. Glucose Homeostasis Optimization: Rau bodybuilders, tshwj xeeb tshaj yog thaum lub sij hawm nruj cov kev pab cuam poob rog siv cov tshuaj insulin sensitizers lossis nrog kev tswj cov khoom noj kom zoo, liraglutide lub peev xwm los txhawb cov insulin secretion tsuas yog thaum cov ntshav qabzib nce siab pab tswj cov qib zog thiab muaj peev xwm txhim kho cov khoom noj khoom haus.
4. Tsis yog -Excitatory: Nws cov txheej txheem ntawm kev ua yog ywj siab ntawm lub paj hlwb sympathetic. Qhov no txhais tau hais tias cov neeg siv yuav tsis muaj cov tsos mob xws li nro, ntxhov siab, lub plawv dhia ceev, lossis insomnia raws li cov tshuaj stimulant -raws li cov rog rog, yog li pab txhawb kom rov zoo dua thiab pw tsaug zog- tseem ceeb heev rau kev poob rog.
Kev Ntsuam Xyuas Zoo
Liraglutide cov txiaj ntsig tsis yog los ntawm nws cov tshuaj pharmacological nkaus xwb tab sis kuj los ntawm kev tswj hwm kev huv huv, kev ruaj ntseg, thiab kev ua kom zoo ntawm cov txheej txheem hauv peptide engineering nws tus kheej. Lub ntsiab zoo yog raws li nram no:
**Ib. Cov khoom ruaj khov vim yog kev hloov pauv fatty acid: **
- ncua kev degradation los ntawm kev khi rau plasma albumin
Ib nrab -lub neej tshaj 13 teev
Txhawb ib zaug - noj txhua hnub
- Khaws cov tshuaj ntshav kom ruaj khov, kom tsis txhob muaj qhov hloov pauv loj heev
II. Kev xaiv agonist zoo heev ntawm GLP-1 receptors:
- Txhawb kev tsim cov tshuaj insulin
- inhibits glucagon
- Ua rau lub plab zom mov qeeb
- Txhim kho cov cim qhia kev qab los noj mov
Cov txheej txheem no ua rau nws lub hnub qub peptide, muaj ob qho tib si cov ntshav qabzib - txo qis thiab qhov hnyav - tswj cov teebmeem.
III. Multifunctional Metabolic Improvement Effects: Cov kev tshawb fawb soj ntsuam tau pom tias liraglutide tuaj yeem txhim kho:
Glycemic tswj
Pancreatic muaj nuj nqi
- Qhov hnyav thiab lub cev rog feem pua
- Cov cim qhia txog kev pheej hmoo plawv
Tsis yog -Alcoholic fatty siab kab mob (NASH)
IV. Qhov zoo ntawm Raw Material Powder:
High purity thiab tswj purity
- Tsawg impurity peaks
- Zoo lyophilization stability
Yooj yim los npaj rau hauv ntau hom tshuaj txhaj tshuaj
Cov txheej txheem paub tab ua kom loj - nplai ntau lawm
Cov txiaj ntsig no ua rau nws tus qauv kub rau GLP-1 tshuaj thoob ntiaj teb. Ntu V Cov Txheej Txheem Kev Tsim Khoom thiab Kev Tswj Xyuas Purity
Liraglutide feem ntau yog npaj siv cov khoom siv -theem peptide synthesis (SPPS) technology. Cov txheej txheem tseem ceeb ntws suav nrog:
Stepwise peptide saw elongation
Kev kho deprotection
Fatty acid chain coupling
Hydrofluoric acid kho thiab pyrolysis
Cov txheej txheem purification (rov qab- theem siab- ua kua chromatography)
Txias- kom qhuav los npaj hmoov
Kev tswj kom zoo muaj xws li:
- Siab-kev ua haujlwm ua kua chromatography purity testing
- Mass spectrometry molecular hnyav paub meej
- Kev txheeb xyuas qhov sib npaug ntawm Amino acid
- Kev tshawb nrhiav cov kuab tshuaj seem
Endotoxin thiab microbial nrhiav pom
High - cov ntaub ntawv raw khoom zoo yuav tsum ua tau raws li ICH thiab cov tshuaj pharmacopoeia kom ntseeg tau tias muaj kev nyab xeeb thiab ua tau zoo ntawm cov qauv.
Peb Qhov Zoo
1. Zoo: Txhua yam khoom tau dhau los ntawm peb cov kws tshaj lij thiab tau lees paub ISO.
2. Nqe: Raws li peb yog lub Hoobkas, peb cov nqi qis dua peb cov neeg sib tw. Cov luv nqi muaj rau kev txiav txim ntau.
3. Shipping: Peb muaj cov Tshuag txaus thiab tuaj yeem xa tuaj hauv 24 teev tom qab them nyiaj.
4. Kev xa rov qab txoj cai kom ua kom cov neeg siv khoom tau txais txiaj ntsig zoo tshaj plaws thiab txo qhov kev poob qis.
5. Zoo heev tom qab- kev muag khoom: Taug qab koj cov xwm txheej pob mus txog thaum xa khoom thiab ua txhua yam los daws cov teeb meem uas cov neeg siv khoom ntsib.
Cim npe nrov: Kev tshawb fawb-cov tshuaj peptide tshwj xeeb Liraglutide 2mg/vial, Tuam Tshoj Kev Tshawb Fawb -cov tshuaj peptide tshwj xeeb Liraglutide 2mg/vial manufacturers, lwm tus neeg, Hoobkas
