Oxytocin: Ib Txoj Kev Ncaj Ncees Ntawm Lub Cev thiab Kev Xav
I. Khoom Keeb Kwm
Kev tshawb fawb tshawb fawb txog oxytocin tau pib thaum xyoo pua 20th thaum cov kws tshawb fawb pom tias cov khoom rho tawm los ntawm cov qog pituitary tom qab tuaj yeem ua rau cov qog nqaij hlav hauv tsev menyuam. Xyoo 1953, American biochemist Vincent du Vigneaud tau ua tiav thawj zaug ua tiav cov khoom sib txuas ntawm oxytocin, uas nws tau txais 1955 Nobel nqi zog hauv Chemistry. Qhov kev ua tiav thaj av no tsis yog tsuas yog nthuav tawm cov tshuaj lom neeg ntawm nws cov nonapeptide tab sis kuj tau coj mus rau lub sijhawm tshiab ntawm kev tshawb fawb ntawm cov tshuaj hormones polypeptide. Los ntawm nws thawj zaug siv ua haujlwm-inducing txhaj tshuaj nyob rau hauv obstetrics rau nws tam sim no raws li ib tug "kev hlub hormone" nyob rau hauv neuroscience, txiav txim siab kev ntseeg, kev sib txuas, thiab kev coj cwj pwm, kev tshawb fawb ciam teb ntawm oxytocin txuas ntxiv mus, ua rau nws yog ib qho tseem ceeb molecule txuas physiology thiab social psychology.
II. Khoom Parameters
oduct Parameters
Lub Npe Lub Npe: Oxytocin
CAS No.: 50-56-6 (Dawb Acid), 6233-83-6 (Acetate)
Molecular Formula: C₄₃H₆₆N₁₂O₁₂S₂
Molecular Luj: 1007.19 Da
Amino Acid Sequence: Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH₂ (muaj ib daim ntawv cog lus disulfide)
Cov tsos mob: Dawb amorphous hmoov
Purity: Ntau dua lossis sib npaug li 98% (HPLC)
Solubility: Yooj yim soluble hauv dej, soluble hauv DMSO
Cia Lub Sijhawm: Khaws ntawm -20 degree, tiv thaiv lub teeb, noo noo, thiab oxidation.
III. Core Functions
Smooth Muscle Contraction: Raws li ib tug classic reproductive hormone, nws ua ncaj qha rau uterine du nqaij, pab txhawb nws contraction zaus thiab lub zog; Tib lub sijhawm, nws txhawb kev cog lus ntawm cov hlwb myoepithelial nyob ib ncig ntawm cov ducts mammary, txhawb kev tshem tawm cov mis nyuj.
Kev Tswj Tus Cwj Pwm: Raws li lub hauv paus neurotransmitter, nws tswj hwm amygdala kev ua los ntawm cov ntshav - lub hlwb thaiv lossis vagal paj hlwb hloov pauv, txhim kho kev ntseeg ntawm tus kheej, kev xav, thiab kev sib txuas, tau txais nws lub npe ntawm "social lubricant."
Stress Buffering Mechanism: Nws tuaj yeem cuam tshuam kev ua haujlwm ntau dhau ntawm hypothalamus-pituitary-adrenal axis (HPA axis), txo qis cov tshuaj hormones kev ntxhov siab xws li cortisol, yog li tsim tawm los tiv thaiv- ntxhov siab, sedative, thiab kev tiv thaiv kab mob plawv.
Anti-inflammatory thiab Healing Properties: Nws muaj cov tshuaj tiv thaiv kab mob antioxidant thiab tiv thaiv- cov khoom ua kom mob, tiv thaiv lub cev los ntawm kev raug mob thiab kev ntxhov siab, thiab txhawb kev kho cov ntaub so ntswg thiab kho qhov txhab.
IV. Core Zoo
Dual Role Synergistic: Nws plays ob lub luag hauj lwm raws li ob qho tib si peripheral hormone ( tswj kev yug menyuam thiab lactation) thiab lub hauv paus neurotransmitter ( tswj kev xav thiab kev sib raug zoo), ua rau nws yog ib qho qauv zoo rau kev kawm siab - lub cev sib cuam tshuam mechanisms.
Kev tswj hwm ntau haiv neeg: Ntxiv nrog rau cov tshuaj txhaj tshuaj rau obstetric thaum muaj xwm txheej ceev, kev tsim cov tshuaj tsuag qhov ntswg tso cai rau kev nkag mus rau cov ntshav zoo- lub hlwb thaiv, muab txoj hauv kev yooj yim rau kev kho cov kab mob neurological.
Muaj peev xwm kho tau dav: Tshaj li nws cov ntawv thov kev tsim kho obstetric, nws pom tau tias muaj peev xwm tseem ceeb hauv kev tshawb fawb soj ntsuam thoob plaws kev puas siab puas ntsws xws li autism spectrum disorder (ASD), kev ntxhov siab hauv zej zog, kev nyuaj siab tom qab yug me nyuam, thiab kev siv yeeb tshuaj tshem tawm.
Natural Bioactivity: Raws li cov tshuaj endogenous nyob rau hauv tib neeg lub cev, nws muaj dav faib receptors thiab ib tug zoo-txoj kev txiav txim, muab zoo biocompatibility thiab kev nyab xeeb profile piv rau cov tshuaj hluavtaws.
V. Siv tau Scenarios
Clinical Obstetrics thiab Gynecology: Siv rau kev ua haujlwm induction, ntxiv dag zog rau lub tsev menyuam atony thaum lub sijhawm ua haujlwm, tiv thaiv thiab kho ntshav qab zib, thiab pab ua kua mis tom qab yug menyuam.
Neuroscience thiab Kev Tshawb Fawb Txog Kev Nyuaj Siab: Tshawb nrhiav cov txheej txheem pathological ntawm kev puas siab puas ntsws, schizophrenia, thiab kev phobia, thiab ntsuas nws cov txiaj ntsig hauv kev txhim kho kev paub txog kev sib raug zoo.
Kev tshawb fawb endocrinology: Kev tshuaj xyuas nws cov txheej txheem ntawm kev ua haujlwm hauv kev ntxhov siab, kev tswj cov metabolism, thiab kev sib txuas ntawm cov kab mob endocrine.
Kev Txhim Kho Tshuaj: Kev tsim cov tshuaj tshiab tshiab los ua cov tshuaj txhuas rau kev kho cov kev xav tsis zoo lossis txhim kho kev sib raug zoo.
VI. Cov kev ceev faj
Kev Saib Xyuas Kev Kho Mob nruj: Raws li cov tshuaj siv tshuaj (xws li kev txhaj tshuaj), nws yuav tsum tau siv raws li kev saib xyuas ntawm cov kws kho mob hauv tsev kho mob. Tus kheej- kev tswj hwm yog txwv nruj kom tsis txhob muaj qhov uterine rupture los yog fetal teeb meem.
Kev Txwv Kev Siv Kev Tshawb Fawb: Chav kuaj- qib hmoov yog rau kev sim tsiaj lossis kev tshawb fawb hauv vitro nkaus xwb thiab tsis tuaj yeem siv rau tib neeg txhaj tshuaj.
Contraindication Screening: Contraindicated nyob rau hauv cov poj niam cev xeeb tub uas muaj teeb meem cephalopelvic disproportion, txawv txav fetal txoj hauj lwm, placenta previa, los yog keeb kwm ntawm cesarean seem; contraindicated nyob rau hauv cov neeg mob uas paub hypersensitivity rau cov khoom no.
Kev Saib Xyuas Kev Mob Nkeeg: Kev siv tshuaj ntau yuav ua rau qaug dej, kub siab, lossis arrhythmia; ntau npaum thiab infusion npaum li cas yuav tsum tau nruj me ntsis tswj.
VII. Dab Neeg Zoo
Hauv kev sim tshuaj ntsuam xyuas rau cov neeg mob nrog frontotemporal dementia (FTD), cov kws tshawb fawb tau siv cov tshuaj tua kab mob hauv qhov ntswg oxytocin. Cov txiaj ntsig tau pom tias tom qab lub sijhawm kho, cov neeg mob lub sijhawm ntev - cov tsos mob apathy tau txhim kho tau zoo, thiab cov ntaub ntawv ntawm lub paj hlwb tau lees paub qhov tshwj xeeb ua kom lub hlwb thaj tsam cuam tshuam nrog kev tswj kev xav. Txoj kev tshawb no, luam tawm nyob rau hauv The Lancet Neurology, qhia tau hais tias oxytocin tsis yog tsuas yog txhim kho cov neeg mob lub neej zoo, tab sis kuj muab thawj qhov kev kho mob uas siv tau rau cov kab mob neurodegenerative uas tam sim no tsis muaj kev kho mob zoo.
Meticulous craftsmanship nyob rau hauv kev tshawb fawb peptide, zoo yog lub hauv paus ntawm kev ua tau zoo.
Tsom ntsoov rau siab -kawg peptide raw cov ntaub ntawv, ua tib zoo craftsmanship kom zoo.
Tau qhov chaw peptide Hoobkas, siab purity rau ntau dua kev ntseeg.
Cim npe nrov: High-purity peptide tshuaj Oxytocin 2mg/vial, Tuam Tshoj High-purity peptide tshuaj Oxytocin 2mg/vial manufacturers, lwm tus neeg, Hoobkas
