Khoom Taw Qhia:
Humanin yog ib qho endogenous luv- saw peptide pib pom hauv kev tshawb fawb txog cov kab mob neurodegenerative. Tsim los ntawm 24 amino acids, nws yog ib qho ntawm ob peb paub ua haujlwm peptides muab los ntawm mitochondrial genome. Qhov kev tshawb pom ntawm humanin tau tig mus rau qhov kev nkag siab ib txwm hais tias mitochondria tsuas yog lub luag haujlwm rau lub zog metabolism, ua rau nws yog tus tswv cuab tseem ceeb ntawm "mitochondrial signaling peptide" tsev neeg. Nrog rau kev tshawb fawb tob zuj zus hauv thaj chaw xws li tiv thaiv- kev laus, bioenergetics, thiab kev tiv thaiv ntawm tes, humanin tau maj mam dhau los ua qhov kev tshawb fawb hotspot hauv kev tshawb fawb txog lub neej thiab biomedicine. Los ntawm kev pom cov khoom siv raw, siab -zoo humanin feem ntau muaj nyob rau hauv daim ntawv ntawm cov peptides hluavtaws thiab yog siv dav hauv kev tshawb fawb, kev sim tshuaj, thiab kev tshawb fawb biotechnology siab heev.
1. Kev faib ua pawg
Raws li daim ntawv thov thiab cov qauv zoo, humanin raw khoom peptides tuaj yeem muab faib ua pawg hauv qab no:
Qeb 1: Kev tshawb fawb-qib Humanized Peptides
Cov khoom no tsuas yog siv rau kev sim ntawm tes, kev tshawb fawb tsiaj, thiab kev tshawb nrhiav tshuab. Purity feem ntau yog nyob nruab nrab ntawm 95% thiab 98%, ua tau raws li cov kev xav tau ntawm kev tshawb fawb feem ntau, nrog rau cov kev xav tau meej meej rau cov khoom sib xws thiab traceability.
Qeb 2: Siab -Kev Tshawb Fawb Kev Ntshiab-Qib Humanized Peptides
Purity feem ntau nce mus txog 98% lossis siab dua, txawm tias 99%, haum rau cov kev tshawb fawb muaj txiaj ntsig zoo rau cov txiaj ntsig kev sim, xws li kev taw qhia txoj hauv kev tsom xam thiab kev soj ntsuam receptor binding. Cov khoom no muaj cov qauv siab dua hauv kev sib txuas, kev ua kom huv, thiab tshawb nrhiav.
Qeb 3: Custom-Modified Humanized Peptides
Cov peptides no yog tsim los ntawm optimizing lawv cov qauv los yog hloov cov amino acids raws li lawv cov natural sequences los txhim kho lawv stability los yog bioactivity. Lawv feem ntau siv rau hauv kev txiav - kev tshawb fawb ntug thiab kev txhim kho cov peptides tshiab.
2. Qhov tseem ceeb zoo thiab nta
Humanin lub ntsiab kom zoo dua yog nyob rau hauv nws dav -spectrum cell-cov khoom tiv thaiv thiab mitochondrial regulatory muaj peev xwm. Cov kev tshawb fawb tau pom tias Humanin muaj txiaj ntsig zoo tiv thaiv cov cim apoptotic nyob rau hauv ntau lub cellular stress, tshwj xeeb tshaj yog nyob rau hauv neurons, cardiomyocytes, thiab pancreatic -cells.
Nws cov txiaj ntsig tseem ceeb suav nrog:
Ua ntej, nws muaj qhov tseem ceeb los tiv thaiv -apoptotic peev xwm, inhibiting kev ua ntawm ntau yam pro-apoptotic proteins.
Qhov thib ob, nws tiv thaiv cov hlwb los ntawm oxidative kev nyuaj siab thiab lub zog metabolism tsis zoo.
Thib peb, nws muaj peev xwm cuam tshuam thiab tswj txoj hauv kev cuam tshuam nrog kev qhia txog insulin, o, thiab kev laus.
Plaub, nws muaj qhov hnyav molecular me me, zoo - qauv tsim, thiab yooj yim rau kev sib txuas thiab hloov kho, muab kev tswj tau zoo hauv kev tshawb fawb.
3. Physicochemical Properties
Tib neeg peptides yog me me molecule peptides nrog ib qho hnyav molecular ntawm kwv yees li 2.6 kDa. Txawm hais tias cov qauv ruaj khov, lawv muaj kev nkag siab rau ib puag ncig. Lawv cov yam ntxwv physicochemical yog raws li nram no:
Lawv yog cov hmoov zoo ntawm chav tsev kub thiab tsis yog -volatile.
Lawv yooj yim soluble nyob rau hauv dej thiab tsis muaj zog buffer kev daws teeb meem, nrog zoo solubility nyob rau hauv nruab nrab los yog weakly acidic tej yam kev mob.
Cov qauv yuav degrade nyob rau hauv siab kub, muaj zog acid, los yog muaj zog alkaline tej yam kev mob.
Lawv rhiab heev rau rov khov dua -thaw cycles; aliquoting raug pom zoo rau kev siv sijhawm ntev -. Lawv cov ntsiab lus isoelectric nyob ze rau nruab nrab, thiab cov khoom siv tshuaj yog qhov me me, ua rau lawv haum rau ntau yam hauv vitro kev sim tshuab.
4. Cov tsos thiab xim yam ntxwv
Siab -cov ntaub ntawv zoo tib neeg peptide raw cov ntaub ntawv feem ntau yog dawb los yog tawm -cov hmoov lyophilized dawb nrog cov xim zoo nkauj thiab zoo ib yam. High-cov khoom purity qhia tsis pom cov impurities lossis cov khoom tsis muaj xim.
Yellowing los yog clumping feem ntau yog cuam tshuam nrog kev ua kom huv tsis txaus, cov av noo ntau dhau, lossis nqus dej noo thaum thauj. High-cov khoom siv zoo tib neeg tsim tau raws li cov lus qhia tshwj xeeb yuav tsum muaj cov qauv xoob, ntxeem tau hmoov tom qab khov- kom qhuav kom yooj yim thiab nrawm dua.
5. Kev piav qhia luv luv ntawm Mechanism of Action
Ntawm qib molecular, humanized compounds siv lawv cov teebmeem los ntawm ntau txoj hauv kev. Ntawm ib sab, lawv tuaj yeem cuam tshuam ncaj qha nrog rau cov pro-apoptotic proteins, thaiv cov xov tooj ntawm tes tuag; ntawm qhov tod tes, lawv tseem tuaj yeem qhib qhov kev qhia ntawm kev tiv thaiv ntawm tes-cov noob muaj feem cuam tshuam los ntawm daim nyias nyias receptor- txoj hauv kev kho kom haum xeeb.
Tsis tas li ntawd, humanized compounds yog ze ze rau kev ua haujlwm mitochondrial thiab suav tias yog "tus kheej- tiv thaiv cov cim taw qhia" tso tawm los ntawm cov hlwb hauv kev ntxhov siab, muaj peev xwm muaj txiaj ntsig hauv lub zog homeostasis thiab kev tswj hwm cov metabolism.
Yuav Order li cas?
Ua ntej, thov qhia peb txog koj qhov kev xav tau lossis daim ntawv thov scenario.
Thib ob, peb yuav muab cov lus hais raws li koj xav tau lossis peb cov lus qhia.
Thib peb, tus neeg siv khoom lees paub cov qauv thiab them tus nqi tso nyiaj.
Plaub, peb muaj lub luag haujlwm rau kev npaj ntau lawm. Cov luv nqi muaj rau kev txiav txim ntau.
Koj cov khoom zoo li cas? Ua ntej, peb cov khoom zoo yog zoo heev thiab ruaj khov. Peb ua 100% kuaj ua ntej xa zaub mov.
Yog li ntawd, peb ua nruj tswj xyuas ua ntej ua zaub mov xa tuaj. Yog tias muaj teeb meem zoo tau pom los ntawm peb, peb yuav hloov cov khoom lossis muab cov nyiaj rov qab dawb.
Yuav ua li cas los tsim kom muaj lub sijhawm ntev -, kev koom tes zoo nrog peb?
1. Peb hais kom muab siab - cov khoom zoo thiab cov nqi sib tw kom ntseeg tau cov neeg siv khoom zoo;
2. Peb hwm txhua tus neeg siv khoom, saib lawv li phooj ywg, thiab ua siab dawb ua lag luam thiab ua phooj ywg nrog lawv, txawm lawv tuaj qhov twg los.
Cim npe nrov: siab-purity peptide humanin 10mg/vial, Tuam Tshoj siab-purity peptide humanin 10mg/vial manufacturers, lwm tus neeg, Hoobkas
