Ara-290: Spatiotemporal Architect ntawm Nerve Injury
Ua txhaum los ntawm kev kho cov paj hlwb ib txwm muaj, Ara-290 yog thawj neuroimmune interface topological reconstruction peptide. Nws yog lub hom phiaj ntawm EphB2 receptor nyob rau hauv dorsal cag ganglion, tshem tawm "mob nco" ntawm neuropathic mob yam tsis muaj kev cia siab rau txoj kev opioid. Nws qhov tshwj xeeb tshwj xeeb yog nyob rau hauv nws lub peev xwm los tsim kho peb - qhov sib txawv spatiotemporal kev tswj hwm ntawm cov hlab ntsha puas ntsoog- coj Schwann cov hlwb kom txav mus los ntawm cov hlab ntsha endomembrane, ib txhij ua kom muaj kev ncaj ncees ntawm cov ntshav - paj hlwb barrier thiab lub zog oschitochillticondrial crosses, leap los ntawm microscopic kho kom haumxeeb reconstruction.
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Lub npe |
Ara-290 |
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Qhov tshwm sim |
Dawb khov- cov hmoov qhuav |
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Purity |
99%+ |
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Yam tsawg kawg nkaus |
10 vials/kit |
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Vaj tse/Nation |
Shenzhen, Suav teb |
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Tau txais txoj kev them nyiaj |
BTC / USDT / Lub txhab nyiaj hloov pauv / Western Union |
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Lub sijhawm thauj mus los |
Nyob ib ncig ntawm 10-15 hnub |
Cov ntsiab lus:
ARA-290: Ib qho yooj yim Molecule Taug kev Tightrope Ntawm "Kho" thiab "Hematopoiesis"
ARA-290, tseem hu ua cibinetide, tsis yog qhov loj hlob ntawm qhov kev xav ib txwm muaj, tab sis yog qhov tseeb "cov ntaub so ntswg diplomat." Muab tau los ntawm peb qhov - qauv qauv ntawm erythropoietin (EPO), nws ntse tshem tawm EPO qhov feem ntau cuam tshuam txog hematopoietic, khaws cia tsuas yog nws cov ntaub so ntswg muaj zog tiv thaiv thiab tiv thaiv - cov khoom inflammatory. Qhov no ua rau ARA-290 yog qhov tseem ceeb tshwj xeeb rau kev tshawb nrhiav neuroprotection, kev tiv thaiv kab mob, thiab kev tsim cov ntaub so ntswg; nws tus nqi yog nyob rau hauv meej lub hom phiaj, tsis yog crude broad-spectrum stimulation.
Qhov zoo: Qhov tseeb "Cellular Protection" Signalman
Qhov txiaj ntsig tseem ceeb ntawm ARA-290 nyob rau hauv nws qhov tseeb "de-hematopoietic" tsim. Los ntawm kev ua raws li B-chain helical qauv ntawm EPO, nws tshwj xeeb activates "innate kho receptor" (IRR), ib tug receptor dav faib rau saum npoo ntawm neurons, endothelial hlwb, thiab lub cev tiv thaiv kab mob. Nws qhov zoo yog xav txog peb yam:
Nws tuaj yeem cuam tshuam qhov polarization ntawm macrophages ntawm pro-mob M1 hom, thaum txhawb lawv txoj kev hloov mus rau kev tiv thaiv - mob thiab kho- txhawb nqa M2 hom. Hauv cov qauv mob ntshav qab zib neuropathy thiab periapical periodontitis, nws txo qis cov theem ntawm inflammatory yam xws li TNF- thiab IL-1 los ntawm txoj kev xws li SIRT1/NF-κB, ua "firewall" nyob rau hauv lub ntsej muag ntawm inflammatory cua daj cua dub.
Cov tshuaj tiv thaiv neuroprotective zoo heev thiab cov ntaub so ntswg- tiv thaiv kev ua haujlwm: Nws tuaj yeem hla cov ntshav- lub hlwb thaiv thiab ua ncaj qha rau hauv nruab nrab paj hlwb, inhibiting neuronal apoptosis thiab txhawb nqa axonal regeneration. Hauv cov qauv ntawm lub raum ischemia / reperfusion raug mob, kev siv thaum ntxov tuaj yeem txhim kho lub raum ua haujlwm thiab txo qis rau mob raum.
Qhov no yog nws qhov zoo tshaj plaws tshaj li ntuj EPO. Nws tsis txhawb cov pob txha pob txha hematopoiesis, yog li zam kev pheej hmoo ntawm cov hlab plawv loj xws li thrombosis thiab mob stroke tshwm sim los ntawm kev loj hlob ntawm erythrocyte ntau dhau, ua rau nws muaj kev cia siab ntau dua nyob rau lub sijhawm ntev - kev nyab xeeb.
Qhov luv -Lub neej Pharmacokinetic Dilemma
Txawm li cas los xij, ARA-290's Achilles's pob taws nyob hauv nws cov ntshav plasma luv heev ib nrab-lub neej. Tom qab txhaj tshuaj, nws cov haujlwm tsuas yog siv li 2 feeb xwb. Cov yam ntxwv metabolic no txhais tau hais tias nws yog qhov nyuaj los tswj kom muaj kev ruaj khov, muaj kev txhawb nqa kev kho mob nyob rau hauv vivo, txo qis nws cov kev kho mob txhais lus zoo. Txawm hais tias nws muaj peev xwm hla cov ntshav-hlwb teeb meem, nws lub sij hawm nyob luv luv ua rau nws nyuaj los tsim kev cuam tshuam ntev rau cov kab mob hauv lub paj hlwb. Qhov kev txwv no yuam cov kws tshawb fawb los siv cov tshuab xa tshuaj nyuaj xws li microneedles thiab hydrogels kom ua tiav qhov kev tso tawm tsis tu ncua, uas ua rau muaj kev nyuaj siab thiab nqi ntawm nws daim ntawv thov.
Cim npe nrov: high efficiency ara-290, Tuam Tshoj high efficiency ara-290 manufacturers, lwm tus neeg, Hoobkas
