Txoj Kev Muaj Cai (Clinical Protocol / Research-Level Guidelines)
Txoj Kev: Kev txhaj tshuaj subcutaneous nkaus xwb (SC); alternating ntawm lub plab (periumbilical ntau dua los yog sib npaug li 2 cm), lateral ncej puab, thiab dorsal sab caj npab; IV/IM yog contraindicated.
Zaus: Ib zaug ib lub lim tiam, tib hnub ntawm lub lim tiam, tsis cuam tshuam los ntawm kev noj zaub mov.
Dosage titration (4-lub lim tiam increments rau Phase III, 2-lub lim tiam increments rau Phase II)
Pib koob tshuaj: 0.6 mg / lub lis piam (0.3 mg nyob rau hauv ib co kev kho mob)
Nce txhua 4 lub lis piam: 0.6 → 1.2 → 2.4 → 3.6 → Kev saib xyuas koob tshuaj 3.6 lossis 4.8–6.0 mg / lub lis piam
Lub hom phiaj kho koob tshuaj: Kev rog 4.8–6.0 mg; MAS 2.4–4.8 mg; T2DM 0.3-2.7 mg (nyob ntawm seb txoj kev kho mob)
Kev kho dua tshiab hauv kev kawm vials (siv 10 mg lyophilized hmoov ua piv txwv)
Solvent: Sterile antimicrobial water (BAC water) maj mam hliv rau ntawm phab ntsa vial, maj mam swirled mus sib tov, tsis txhob vortex
Ntim: Ntxiv 2 mL → 5 mg / mL (1 unit U-100=50) µg)
Aspiration: Hloov cov chav nyob raws li lub rooj titration, tig qhov chaw txhaj tshuaj.
Cov kev phiv tshwm sim ntau: koob tshuaj - nyob ntawm cov kab mob plab zom mov ( xeev siab ~ 66%, raws plab ~ 49%, ntuav ~ 41%), feem ntau tshwm sim hauv thawj 6 lub lis piam ntawm titration; qeeb titration tuaj yeem txo tus nqi txiav tawm.
Contraindications: Rau kev tso npe tshuaj ntsuam xyuas lossis kev tshawb fawb RUO nkaus xwb; tus kheej- txhaj tshuaj/siv yog txwv nruj heev.
Daim ntawv thov Scenario
Ntev- tswj qhov hnyav hauv cov neeg laus rog / rog rog (BMI Ntau dua lossis sib npaug li 27 kg / m², nrog lossis tsis muaj T2DM; SYNCHRONIZE-1/2)
MASH (metabolic steatohepatitis, yav tas los NASH) nrog fibrosis F2-F3 (LIVERAGE), them nyiaj cirrhosis F4 (LIVERAGE-Cirrhosis); theem II, kev txhim kho siab tshaj plaws ntawm 48 lub lis piam daim siab biopsy ~ 63.8% vs placebo 15.2%
Hom 2 mob ntshav qab zib mellitus co-Kev tswj cov ntshav qabzib thiab qhov hnyav (HbA1c txo qis tuaj yeem ncav cuag ...) ~ 1.6%, qhov hnyav qis dua thawj ob yam khoom)
Cardiovascular-Renal-Metabolic (CKM) Risk Population (SYNCHRONIZE-CVOT)
Kev cia khoom:
Raws li nws cov qauv tshuaj lom neeg cov yam ntxwv ntawm 29-amino acid peptide thiab C18 fatty acid hloov kho, Survodutide yuav tsum tau khaws cia nruj me ntsis raws li cov lus qhia hauv qab no: Unopened / Powder State: Yuav tsum tau muab kaw thiab tiv thaiv lub teeb, khaws cia rau hauv qhov chaw khov ntawm -20 degree, qhov uas nws feem ntau tuaj yeem ruaj khov rau 3 xyoos; yog tub yees ntawm 4 degree, nws tuaj yeem khaws cia rau 2 xyoos.
Reconstituted/Prepared State: Thaum yaj nyob rau hauv ib tug hnyav, nws yuav tsum tau muab tso rau tam sim ntawd nyob rau hauv ib tug qis -kub ib puag ncig ntawm -80℃(cia rau 6 lub hlis) los yog -20℃(cia rau 1 lub hlis). Rov ua dua lub voj voog khov-thaw yog txwv nruj kom tiv thaiv peptide saw degradation thiab inactivation.
Kev Thauj Mus Los: Feem ntau yog thauj siv cov pob khov nab kuab lossis cov hlua khov khov qhuav kom ntseeg tau tias cov tshuaj tsis tuaj yeem ua rau lub sijhawm thauj mus los.
FAQ
Q: Qhov kev txiav txim yam tsawg kawg nkaus yog dab tsi?
A: Yam tsawg kawg nkaus kom muaj nuj nqis yog 10 fwj / teeb.
Q: Nws siv sijhawm ntev npaum li cas rau nkoj?
A: Hauv - cov khoom xaj yuav raug xa tuaj hauv 24 teev.
Q: Dab tsi purity theem koj tuaj yeem muab tau?
A: Txheem purity 99%.
Q: Qhov kev pabcuam courier koj siv?
A: FedEx, DHL, UPS, thiab kev pabcuam xa ntawv muaj.
Q: Ntev npaum li cas shipping?
A: Kwv yees li 10-15 hnub.
Q: Koj puas tuaj yeem muab COA (Certificate of Account) daim ntawv tshaj tawm kev soj ntsuam zoo thiab HPLC (High-Performance Computing) qhia?
A: Yog lawm, tag nrho cov khoom raug kuaj xyuas ua ntej ua zaub mov xa tuaj.
Q: Koj puas txhawb OEM hom?
A: OEM branding tau txais kev txhawb nqa, raws li qhov yuav tsum tau ua kom tsawg kawg nkaus kom muaj nuj nqis.
Q: Dab tsi yog koj tom qab - nqe lus muag khoom?
A: Tom qab tus neeg siv khoom tau txais cov khoom, yog tias qhov teeb meem zoo tau lees paub los ntawm peb cov khoom, lawv tuaj yeem txaus siab rau kev hloov pauv dawb lossis nyiaj rov qab. Peb ua raws li lub hauv paus ntsiab lus ntawm kev ua haujlwm thiab lub luag haujlwm, ua tib zoo teb thiab daws txhua yam teeb meem, yam tsis muaj lub luag haujlwm lossis zam teeb meem, thiab tiv thaiv cov neeg siv khoom muaj cai.
Q: Txoj kev them nyiaj twg muaj?
A: Peb txhawb nqa kev hloov pauv hauv txhab nyiaj, Bitcoin, Hloov pauv, thiab Xoom.
Cim npe nrov: survodutide 10mg / vial txo cov rog tawv thiab txhim kho cov metabolism. cas: 2805997-46-8, Tuam Tshoj survodutide 10mg / vial txo cov tawv nqaij rog thiab txhim kho cov metabolism. cas: 2805997-46-8 manufacturers, lwm tus neeg, Hoobkas
