I. Khoom Paub meej
Selank yog ib qho hluavtaws heptapeptide nrog cov kab ke Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP). Nws yog ib tug structurally optimized analog ntawm tib neeg endogenous immunomodulatory peptide Tuftsin. Los ntawm kev txuas ntxiv Pro-Gly-Pro fragment ntawm C-terminus, nws ua kom muaj kev ruaj ntseg metabolic thiab lub hauv nruab nrab lub paj hlwb kev ua si, nthuav tawm ob qho tib si neural thiab immunomodulatory zog.
II. Khoom Parameters
CAS Nr .: 129954-34-3
Molecular Formula: C₃₃H₅₇N₁₁O₉
Molecular Luj: Kwv yees . 751.89 Da
Cov tsos mob: Dawb los yog tawm -dawb xoob lyophilized hmoov
Purity: Kev tshawb fawb qib siab dua lossis sib npaug li 98% / Pharmaceutical qib Ntau dua lossis sib npaug rau 99.5% (HPLC)
Solubility: Yooj yim soluble hauv dej, PBS, thiab physiological saline; insoluble nyob rau hauv nonpolar organic solvents
Kev ruaj ntseg: Cov hmoov qhuav tuaj yeem khaws cia ruaj khov rau ntau dua lossis sib npaug li 2 xyoos ntawm -20℃tiv thaiv los ntawm lub teeb; aqueous tov tuaj yeem khaws cia ruaj khov rau 3 lub hlis ntawm 4 degree; dawb ntawm yooj yim oxidized residues, siab tshuaj stability
III. Product Functions thiab Effects
Anti-Txoj kev ntxhov siab thiab kev tswj hwm lub siab: Raws li qhov zoo allosteric modulator ntawm GABA-A receptors, nws txhim kho inhibitory neurotransmission, zoo txo kev ntxhov siab, ntshai, thiab aggression, thiab tsis tshua muaj peev xwm ua rau sedation thiab dependence feem ntau pom nyob rau hauv benzodiazepines.
**Nootropic thiab Stress-Resistant Effects:** Tswj cov metabolism ntawm monoamine neurotransmitters xws li serotonin thiab dopamine, txhim kho kev puas siab puas ntsws, kev kawm thiab kev nco, thiab txo cov kev ntxhov siab.
**Neurotrophic thiab tiv thaiv teebmeem:** ceev ceev upregulates kev qhia ntawm lub hlwb-derived neurotrophic factor (BDNF) nyob rau hauv lub hippocampus, txhawb neuronal ciaj sia taus thiab synaptic plasticity.
** Kev tswj hwm lub cev tsis muaj zog:** Kev tsim cov khoom ntawm tuftsin, nws tswj T cell homeostasis thiab cytokine (xws li IL-6) qhia, pab txhawb kev ua haujlwm ntawm macrophage phagocytic.
** IV. Core Advantages: **
**High Safety Homologous Structure:** Cov txheej txheem tseem ceeb yog homologous heev rau tib neeg tuftsin, tsis muaj kev tiv thaiv kab mob thiab tsis tshua muaj peev xwm ntawm inducing antibody teb.
**Kev ruaj ntseg zoo:** C- qhov hloov kho qhov kawg ua rau nws tiv taus kev degradation los ntawm cov ntshav peptidases, uas ua rau lub neej ntev dua li ib nrab ntawm cov tuftsin, thiab nws kuj yog resistant rau cia thiab oxidation inactivation.
** Ntau- phiaj xwm sib koom ua ke: Ib txhij lub hom phiaj GABA, serotonin, dopamine, thiab lub cev tiv thaiv kab mob, ua tiav txoj cai ruaj khov uas yog "tiv thaiv- ntxhov siab yam tsis muaj kev ntxhov siab thiab kev txawj ntse tsis muaj kev ntxhov siab."
Kev ua tau zoo dua qub: Ib lub raj mis hais txog ob qho kev tshawb fawb thiab daim ntawv thov kev xav tau ntawm lub paj hlwb (tiv thaiv-kev ntxhov siab / kev paub txog) thiab kev tiv thaiv kab mob (kev tiv thaiv kab mob).
V. Keeb kwm
Selank tau tsim los ntawm Lub Tsev Haujlwm ntawm Molecular Genetics (IMG RAS) ntawm Lavxias Academy ntawm Kev Tshawb Fawb. Cov kws tshawb fawb tau hloov kho lub cev tiv thaiv kab mob tetrapeptide Tuftsin (Thr-Lys-Pro-Arg) thiab ntxiv Pro-Gly-Pro tripeptide tail kom tiv thaiv cov enzymatic degradation sai hauv lub cev. Qhov kev ua tiav no tau pom zoo los ntawm Lavxias Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv hauv xyoo 2009 rau kev lag luam raws li tshuaj tsuag qhov ntswg (lub npe lag luam Selank) rau kev kho mob ntawm kev ntxhov siab thiab kev ntxhov siab.
VI. Cov kev ceev faj
Kev txwv kev siv: Cov tshuaj reagents no yog rau kev tshawb fawb hauv chav kuaj xwb. Lawv raug txwv nruj heev rau tib neeg tus kheej- kev sim lossis tshuaj txhaj tshuaj (txawm tias cov tshuaj tsuag qhov ntswg muaj nyob rau hauv Russia, hla- ciam teb siv tsis raug tso cai muaj kev pheej hmoo).
Cov txheej txheem tuav: Nws raug nquahu kom lis cov tshuaj reagents hauv lub fume hood thaum hnav hnab looj tes. Rau kev kho dua tshiab, cov dej tsis muaj menyuam / physiological saline raug pom zoo; zam lub zog tshee. Tom qab reconstitution, aliquot thiab khaws cia hauv qab no -20 degree, tsis txhob rov qab khov-thaw mus.
Kev sib xyaw ua ke: zam kev sib koom ua ke ntev nrog cov kua qaub muaj zog, muaj zog alkalis, lossis muaj zog oxidizing cov neeg ua haujlwm.
Selank mus ob peb vas- tswj peptides yog ua tib zoo tsim los ntawm lub chaw tsim khoom peptide, khav theeb siab purity, siab ua haujlwm, nruj tswj hwm, thiab batch stability. Peb tshwj xeeb hauv kev tshawb fawb thiab tsim cov neuro- soothing thiab tiv thaiv -kev ntxhov siab peptides, muab ntau yam kev qhia tshwj xeeb thiab kev xaiv ntim khoom dua tshiab. Peb muab kev xa ncaj qha thoob ntiaj teb los ntawm Tshuag, siv biopeptide thev naus laus zis los txhawb kev txhim kho ntawm neurohealth thiab kev tshawb fawb kev lag luam kev lag luam saw.
Cim npe nrov: High- zoo peptide tshuaj Selank 5mg / vial, Tuam Tshoj High- zoo peptide tshuaj Selank 5mg / vial manufacturers, lwm tus neeg, Hoobkas
