Thaum nws los txog rau IGF-1 LR3 peptide raw cov ntaub ntawv, nws yog ib tug formidable neeg uas ua ntawv nyob rau hauv lub cell kab lis kev cai thiab biopharmaceutical teb. Yog tias cov tshuaj insulin tsis tu ncua yog qhov tseem ceeb rau kev muaj sia nyob ntawm tes, ces IGF-1 LR3 zoo li lub zog "stimulant" rau cov hlwb. Niaj hnub no, cia peb ua tib zoo saib cov khoom xyaw no uas ntau tus kws tshawb fawb nyiam thiab ntxub.
Basic Parameters thiab Physical Mechanisms: Dab tsi yog nws?
IGF-1 LR3 (ntev-chain insulin-zoo li kev loj hlob-1) yog qhov ua tau zoo hloov kho ntawm ntuj IGF-1. Nws qhov hnyav molecular yog kwv yees li 9.1 kDa, muaj li ntawm 83 amino acids. Piv rau ntuj 70-amino acid IGF-1, nws tsuas yog hloov kho ob thaj chaw: ua ntej, nws ntxiv 13-amino acid extension peptide rau N-terminus; thib ob, nws hloov cov glutamic acid ntawm txoj hauj lwm 3 nrog arginine.
Tsis txhob kwv yees ob qhov kev hloov kho no; lawv yog lub hauv paus ntawm nws lub cev mechanism. Thaum cov qog nqaij hlav qog noj ntshav, lawv tso cov protein hu ua "IGF-binding protein (IGFBP)," uas ua haujlwm zoo li tus neeg saib xyuas lub cev, tiv thaiv lub ntuj IGF-1 los ntawm kev ua haujlwm. Txawm li cas los xij, IGF-1 LR3, vim nws qhov kev hloov pauv ntawm cov qauv, muaj ntau dua 1000-fold txo affinity rau cov protein khi no. Qhov no zoo li muab nws lub tsho tsis pom kev, tso cai rau nws kom dhau los ntawm tus neeg saib xyuas lub cev thiab ncaj qha qhib lub IGF-1 receptor (IGF-IR) ntawm lub xovtooj ntawm tes, yog li ua rau muaj kev cuam tshuam ntawm cov kab hauv qab thiab kev tiv thaiv apoptosis.
Cov txiaj ntsig tseem ceeb thiab kev ua haujlwm: Vim li cas siv nws?
Muab cov tshuaj insulin tsis tu ncua thiab ntuj IGF-1, vim li cas thab tsim LR3? Cov lus teb yog yooj yim: efficiency.
Ntev Ntev Ib Nrab -Lub Neej: Ib nrab-lub neej ntawm IGF ntuj-1 hauv vivo tsuas yog ob peb feeb mus rau kaum feeb, thaum LR3 tuaj yeem kav ntev li 20 txog 30 teev. Qhov no txhais tau hais tias ib zaug ntxiv rau cov kab lis kev cai nruab nrab, nws tuaj yeem muab cov txiaj ntsig zoo rau lub sijhawm ntev, tshem tawm qhov kev xav tau ntau zaus - yooj yim thiab ruaj khov.
Exceptional Bioactivity: Nws txoj kev loj hlob - txhawb kev muaj peev xwm yog kaum lossis ntau pua lub sij hawm muaj zog dua li insulin. Tshwj xeeb tshaj yog nyob rau hauv cov ntshav qab zib-dawb lossis qis- cov kab lis kev cai hauv cov kab lis kev cai hauv cov ntshav, nws muaj zog txhawb cov hlwb zoo li CHO thiab HEK293, thiab ua rau muaj txiaj ntsig zoo rau cov txiaj ntsig ntawm cov protein sib txuas (xws li cov tshuaj tiv thaiv thiab tshuaj tiv thaiv).
Kev ruaj ntseg zoo: Piv nrog rau cov tshuaj insulin, LR3 muaj zog dua thaum kab lis kev cai thiab tsis tshua muaj kev puas tsuaj.
Siv tau Scenario: Leej twg xav tau nws tshaj?
Cov tshuaj no feem ntau ua haujlwm nyob rau hauv cov txheej txheem saum toj kawg nkaus hauv cov chaw soj nstuam thiab cov tuam txhab muag tshuaj: nyuaj-rau- cov kab mob kab lis kev cai: xws li cov qia hlwb, thawj cov neurons, chondrocytes, lossis cov leeg nqaij. Cov hlwb "lawv" no nyuaj rau kab lis kev cai nrog cov khoom siv zoo tib yam; ntxiv LR3 ua rau kom lawv cov ciaj sia taus.
Biopharmaceutical Mass Production: Yog tias koj tab tom tsim cov tshuaj tiv thaiv kab mob monoclonal lossis cov kab mob kis kab mob thiab xav tau kom ua tiav cov cell ceev heev, LR3 yog qhov muaj zog heev.
Organoid Kev Tsim Kho: Hauv kev tshawb fawb tshuaj kho dua tshiab, nws feem ntau yog siv los ua kom cov cell sib txawv thiab nthuav dav kom sai sai ua peb - cov qauv ntawm cov ntaub so ntswg.
Qhov tsis zoo thiab ceev faj: Tsis txhob ua qhov muag tsis pom los ntawm nws qhov zoo.
Thaum nws muaj zog, muaj ntau qhov kev nyuaj siab los xav txog thaum siv nws, yuav tsum tau ceev faj ntxiv:
Tus nqi siab: Siab-cov khoom siv zoo LR3 cov khoom siv zoo yog kim, ua rau muaj kev cuam tshuam cov nqi tseem ceeb thaum siv rau qhov loj.
Kev pheej hmoo ntawm hypoglycemic: Vim tias nws cov qauv zoo ib yam li insulin, kev tuav tsis raug lossis ntau dhau yuav ua rau cov piam thaj tsis zoo hauv cov kab lis kev cai (zoo ib yam li cov tshuaj tiv thaiv hypoglycemic).
Receptor Desensitization: Cov tshuaj no muaj zog heev. Ntev - lub sij hawm tas mus li siab - kev sib xyaw ua ke tuaj yeem ua rau cov receptor "tolerance" ntawm cov hlwb, ua rau cov tshuaj ntxiv tom qab tsis zoo. Yog li, kev sim tsim qauv feem ntau yuav tsum tau ncua txhua 4-6 lub lis piam.
Kev Cia Siab: Cov hmoov lyophilized yuav zoo tshaj plaws khaws cia ntawm -20 degree, tiv thaiv los ntawm lub teeb. Tom qab rov kho dua, tsis txhob rov ua kom khov-thaw mus ntxiv, vim qhov no yuav ua rau muaj kev ua haujlwm sai.
Hauv cov ntsiab lus, IGF-1 LR3 yog ob- ntaj ntug. Thaum siv kom raug, nws yog qhov hloov pauv kev ua si rau kev kov yeej cov kab lis kev cai ntawm tes; thaum siv tsis raug, nws tuaj yeem tsis tsuas yog nkim nyiaj xwb tab sis kuj muaj peev xwm ua kom puas tag nrho cov hlwb. Yog li ntawd, ua ntej siv nws, koj yuav tsum nkag siab txog cov yam ntxwv ntawm koj lub hlwb thiab tswj cov koob tshuaj kom zoo.
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