Lub Npe Tag Nrho: Tib Neeg Kev Loj Hlob Hormone Fragment 176-191, abbreviated li HGH Frag 176-191
CAS Naj Npawb: 66004-57-7 (dawb daim ntawv; CAS tus lej rau acetylated / amidated variants txawv me ntsis)
Molecular Formula (tus qauv tsis hloov pauv): C₇₈H₁₂₃N₂₃O₂₃S
Molecular Luj: Kwv yees li 1815–1817 Da (Zoo ze rau AOD9604, AOD9604 muaj Tyr ntxiv, yog li me ntsis loj dua los ntawm ob peb Da)
Sequence: FKDLS (Phe-Lys-Asp-Leu-Ser), piv txwv li, hGH Lub xeem rau cov amino acids ntawm C-terminus; qee cov tuam txhab lag luam muaj kev sib txawv nrog N-terminal acetylation lossis C-terminal amidation los txhim kho kev ruaj ntseg.
Cov tsos mob: Dawb rau tawm -dawb lyophilized hmoov
Purity: Kev tshawb fawb qib feem ntau sau ntau dua lossis sib npaug li 98% (HPLC)
Solubility: Soluble nyob rau hauv dilute acetic acid / sterile dej / antibacterial dej; solubility nyob rau hauv cov dej ntshiab yog tsawg, nws yog pom zoo kom siv dej uas muaj 0.1% acetic acid los yog BAC los pab dissolution.
Cia: Unreconstituted, -20 degree, tiv thaiv los ntawm lub teeb thiab noo noo; reconstituted, refrigerate ntawm 2-8 degree, zoo tshaj plaws siv nyob rau hauv 24-72 teev. Kev rov ua kom khov-thaw yuav ua rau cov hydrophobic luv peptides sib sau ua ke thiab ua tsis muaj zog.
HGH Frag rho tawm rau 6 amino acids los ntawm txoj haujlwm 176 txog 191 ntawm tag nrho -ntev HGH molecule's C-terminus- cheeb tsam no tau pom tias yog qhov chaw ua haujlwm me tshaj plaws rau HGH los khi rau cov chaw tshwj xeeb ntawm adipocytes, 5} cov teebmeem ntawm lipoogenestic
Lub cev Mechanism:
Nws ua ncaj qha rau ntawm GH qhov chaw sib txuas ntawm adipocyte membrane (tsis yog-classical GH receptor, tsis qhib txoj hauv kev JAK2-STAT).
Nws ua rau cov tshuaj hormone-sensitive lipase (HSL) hauv adipocytes, txhawb kev tawg ntawm triglycerides rau hauv cov roj fatty acids dawb rau kev tso tawm.
Nws inhibits lipoprotein lipase (LPL) kev ua si → txo cov reuptake thiab cia ntawm circulating triglycerides los ntawm adipocytes.
Nws tsis txhawb nqa IGF-1 ntau lawm lossis ua kom qis qis GH receptor signaling → yog li tsis muaj cov teebmeem anabolic, cov ntshav qabzib cuam tshuam, thiab cov pob txha / cov nqaij mos hyperplasia cuam tshuam ntawm HGH.
Hauv luv luv: Nws tsuas yog siv ib feem me me ntawm HGH uas "pab zom cov rog thiab tiv thaiv cov rog tshiab los ntawm kev nkag mus," muab pov tseg.
Tsis nce IGF-1: Tsis cuam tshuam rau lub caj pas pituitary, tsis txhob muaj kev pheej hmoo ntawm acromegaly thiab visceral o.
Glycemic Friendly: Tsis cuam tshuam rau insulin rhiab heev; insulin tsis kam / hyperglycemia tshwm sim los ntawm HGH tsis tshwm sim.
Tsis Muaj Cov Teeb Meem Anabolic: Tsim nyog rau cov neeg uas xav ua rog tshwj xeeb yam tsis muaj dej thiab sodium retention lossis carpal tunnel syndrome tshwm sim los ntawm HGH.
Me Me Molecular Luj: Kev nqus sai sai; khov -peptides qhuav yog yooj yim khaws thiab thauj.
Cov Tsiaj Zoo Tshaj Plaws: Cov qauv nas rog rog pom qhov txo qis hauv cov roj ntsha hauv lub cev thiab cov rog subcutaneous, nrog rau cov teebmeem ntawm lipolysis feem ntawm qhov sib npaug ntawm HGH.
Cov pov thawj tsis muaj zog rau tib neeg txo cov rog: Qhia txoj hmoo ntawm AOD9604- siv tau rau cov tsiaj, tab sis nws txoj kev txo cov rog hauv tib neeg tsis tau muaj pov thawj zoo dua rau cov placebo hauv RCTs. Loj -kev sim tshuaj ntsuam xyuas ua tsis tiav ua ntej cov kev tshawb fawb hloov mus rau qhov sib koom ua ke (AOD9604), tsis zoo li HGH. Frag yeej tsis tau pom zoo rau ib qho kev qhia.
Kev khaus khaus hauv zos: liab, o, khaus, thiab qee zaus kub hnyiab ntawm qhov chaw txhaj tshuaj. Cov peptides luv luv yooj yim ua rau tso tawm cov neeg kho mob hauv zos.
Dose-effect ambiguity: Tsis muaj kev pom zoo pom zoo ntawm cov koob tshuaj zoo rau tib neeg. Feem ntau ncig 500-1000 ug / hnub faib cov koob tshuaj yog raws li kev paub hauv lub rooj sab laj es tsis yog kev kho mob.
Tsis muaj cov leeg nce: Tsis txhob cia siab tias nws yuav hloov HGH rau kev nce qib anabolism lossis rov qab los; Nws yog purely lipid metabolism regulator.
Qhov tseem ceeb batch-rau-batch variation: purity thiab sequence raug ntawm unregistered raw cov ntaub ntawv yog inconsistent (txawm nws yog tiag tiag 176-191 los yog tag nrho HGH-cleaved impurities).
Ua ke nrog kev noj zaub mov nruj thiab kev cob qhia, raws li metabolic peptide los pab txo qis cov rog hauv cheeb tsam (qis plab / nraub qaum thiab duav) (tsawg xav tau kev tswj hwm qib).
Rau cov kws tshawb fawb lossis cov neeg nyiam tshaj plaws uas xav paub txog cov txiaj ntsig lipolysis ntawm GH tab sis muaj kev txhawj xeeb txog nws qhov cuam tshuam rau cov ntshav qab zib / IGF-1 / dej tuav.
Kev Tshawb Fawb Kev Siv: Localization ntawm GH lipolysis functional domains, kev tshawb fawb ntawm GH binding qhov chaw hauv adipocytes, hauv vitro qauv ntawm lipid metabolism.
Tsis yog qhov hloov pauv rau cov tshuaj poob phaus, tsis yog rau kev kho mob rog.
Contraindications tsis haum rau peptides, keeb kwm ntawm malignant hlav (theoretically, muaj controversy txog nws cov nyhuv ntawm cov qog microenvironment los ntawm kev txhawb adipocytes metabolism; zam rau kev nyab xeeb yog vim li cas), cev xeeb tub los yog pub niam mis rau cov poj niam, cov me nyuam.
WADA Status: Muaj feem cuam tshuam rau kev loj hlob hormone-cov khoom seem thiab tau teev nyob rau hauv Lub Ntiaj Teb Kev Tiv Thaiv -Doping Agency cov npe txwv tsis pub{2}} txwv tsis pub rau cov neeg ncaws pob koom.
Reconstitution Recommendation: 10mg / vial ntxiv rau 1-2mL ntawm cov tshuaj tua kab mob dej uas muaj 0.1% acetic acid → concentration 5-10mg / mL, maj mam yob, tsis txhob vortex vigorously. Cov ntaub ntawv / cov rooj sib tham feem ntau pom zoo kom txhaj tshuaj subcutaneous ntawm 300-1000 ug ob zaug ib hnub (tag kis + ua ntej kev tawm dag zog), tab sis qhov no yog kev siv empirical yam tsis muaj kev pom zoo rau kev kho mob.
Cov Lus Cim Cia: Khaws ntawm qhov kub qis rau lub sijhawm luv tom qab rov tsim dua; pov tseg tam sim ntawd yog huab lossis tsis muaj xim; lyophilized hmoov clumping raws li kev sib cuag nrog noo noo qhia degradation.
Kev Ceeb Toom Cov Khoom Siv: Cov khoom lag luam muaj nyob rau hauv kev lag luam tsis tau sau npe thiab sau npe "Rau Kev Tshawb Fawb Siv nkaus xwb." Nco ntsoov xyuas Daim Ntawv Pov Thawj Kev Tso Cai (COA) ua ntej yuav khoom (HPLC + MS kev lees paub ntawm 176-191 hexapeptide, tsis yog sib xyaw ntawm tag nrho HGH fragments). Cov khoom cuav muaj ntau.
Kev Tswj Xyuas Kev Cia Siab: Kev cia siab rau nws rau "kev poob phaus" yuav ua rau poob siab. Nws yog qhov zoo tshaj plaws siv los ua ib qho ntxiv ntawm cov kev pab cuam poob phaus, tsis yog cov khoom tseem ceeb.
Nyob rau hauv luv luv: HGH 176-191 fragment yog qhov tsawg tshaj plaws active fragment rau HGH lipolysis, nrog ib tug dav dav kev nyab xeeb qhov rais thiab tsis muaj kev cuam tshuam rau IGF-1 los yog ntshav qab zib. Txawm li cas los xij, nws qhov kev ua tau zoo rau kev poob phaus hauv tib neeg ib leeg tsis muaj pov thawj muaj zog-nws yog qhov tseem ceeb ntsig txog AOD9604. Tsiaj cov ntaub ntawv zoo li zoo, tab sis kev cia siab rau tib neeg siv yuav tsum tau qis dua; nws tsuas muaj qee qhov cuam tshuam thaum ua ke nrog kev noj haus thiab kev tawm dag zog.
Cim npe nrov: Tuam Tshoj peptide hmoov hgh 176/191 (fragment) manufacturers, lwm tus neeg, Hoobkas
