Natural Source: Tib neeg txoj kev loj hlob hormone (hGH) yog ib txwm tso tawm los ntawm cov qog pituitary anterior thiab yog ib qho - saw polypeptide muaj li ntawm 191 amino acids.
Thaum Ntxov Extraction Era (1950s-1985): Pib rho tawm los ntawm cov qog pituitary ntawm cov neeg tuag (pHGH). Txawm hais tias muaj txiaj ntsig zoo hauv kev kho mob dwarfism, nws txoj kev siv tshuaj kho mob tau txwv los ntawm FDA thiab ntau lub tebchaws thoob ntiaj teb hauv xyoo 1985 vim muaj kev tsis txaus ntawm tus neeg pub dawb, kev ua kom huv siab, thiab muaj kev pheej hmoo ntawm kev nqa tus kab mob Creutzfeldt-Jakob (CJD, tus kab mob prion tuag).
Gene Recombination Era (1985-Tam sim no): Siv cov thev naus laus zis DNA recombinant, 191-amino acid-encoding hGH gene fragment yog muab tso rau hauv E. coli los yog mammalian hlwb, ua rau nws nthuav tawm cov protein nrog 100% zoo tib yam qauv rau tib neeg cov protein. Eli Lilly pioneered thev naus laus zis hauv xyoo 1986, thiab Tuam Tshoj tau ua tiav nws hauv xyoo 1988, ua rau nws tsuas yog muaj kev nyab xeeb thiab raug cai tam sim no.
Hom: Recombinant Human Growth Hormone (rhGH)
Amino Acid Length: 191 (sib txawv ntawm qhov ua ntej 192aa/Met-hGH)
Molecular Luj: Kwv yees li 22,125 Da (Molecular Formula: C990H1528N262O300S7)
CAS: 12629-01-5 CAS Nr.
Cov tsos mob: Dawb los yog tawm -dawb lyophilized hmoov (kuaj kho mob, feem ntau yog txhaj, yuav tsum tau tub yees)
Muaj peev xwm: 1 mg anhydrous protein ≈ 3.0 IU (International Units)
Isoelectric Point: pH ~ 5.5
Kev cia khoom: Txias ntawm 2-8℃(lyophilized khoom); Tom qab rov kho dua, nws feem ntau yuav tsum tau muab tso rau hauv tub yees kom deb ntawm lub teeb thiab siv nyob rau hauv lub sijhawm teev tseg.
Kev Txhawb Kev Loj Hlob: Txhawb kev sib txawv thiab kev loj hlob ntawm epiphyseal chondrocytes, txhawb kev loj hlob ntawm cov pob txha (me nyuam yaus).
Protein Synthesis thiab Nitrogen Retention: Txhawb nqa amino acid uptake thiab protein synthesis, txo cov protein ntau, thiab ua kom lub cev hnyav.
Lipolysis: Txhawb kev tawg ntawm cov ntaub so ntswg adipose (lipolysis), txo qis feem pua ntawm cov rog hauv lub cev, tshwj xeeb tshaj yog visceral rog.
Glucose Metabolism Regulation: Antagonizes insulin ua haujlwm (nce ntshav qab zib); Ntev -lub sij hawm los yog siab - siv koob tshuaj tuaj yeem ua rau muaj kev tiv thaiv insulin.
Mineral Metabolism: Txhawb nqa cov calcium, phosphorus, sodium, thiab lwm yam, uas muaj txiaj ntsig zoo rau cov pob txha mineralization.
Indirect Effects: Feem ntau kho los ntawm IGF-1 (insulin-zoo li kev loj hlob factor-1) tsim los ntawm cov ntaub so ntswg xws li lub siab, txhawb kev loj hlob thiab ib feem anabolizing metabolism.
Ua tiav Identtical Structure: Recombinant 191aa muaj tib cov amino acid sib lawv liag thiab spatial qauv raws li lub ntuj tib neeg hGH, nrog tsis tshua muaj immunogenicity (antibody ntau lawm tus nqi<1%), making it less likely to cause allergies.
Tswj Kev Nyab Xeeb: Tshem tawm txoj kev pheej hmoo ntawm kev kis kab mob (xws li CJD) los ntawm kev tshem tawm cadaver.
**Kev Ua Tau Zoo:** Hauv cov ntawv pom zoo (xws li kev loj hlob hormone deficiency (GHD), Turner syndrome, thiab cov menyuam yaus uas muaj lub raum tsis txaus), nws tuaj yeem txhim kho qhov siab kawg nkaus, cov ntsuas metabolic, thiab lub neej zoo.
**Mature Technology:** Cov thev naus laus zis xws li E. coli secretory qhia tau txo cov nqi thiab txhim kho purity thiab kev ua haujlwm.
**Kev tswj hwm txhaj tshuaj:** Feem ntau yog tswj hwm subcutaneously lossis intramuscularly, yuav tsum tau siv sijhawm ntev thiab ntev -, ua rau tsis yooj yim thiab mob rau cov neeg mob (tshwj xeeb yog menyuam yaus).
**Metabolic Side Effects:** Cov kev mob tshwm sim muaj xws li dej thiab sodium retention (edema ntawm tes thiab ko taw, mob pob qij txha, carpal tunnel syndrome), mob nqaij; Nws tuaj yeem ua rau cov tshuaj insulin tsis kam lossis hyperglycemia, thiab ntev - cov koob tshuaj ntev yuav ua rau muaj ntshav qab zib.
**Lwm yam txaus ntshai:** Hypothyroidism (yuav tsum tau saib xyuas), intracranial siab (tsis tshua muaj), thiab femoral taub hau slippage yuav tshwm sim; Nws yog contraindicated nyob rau hauv cov neeg mob uas muaj cov qog nqaij hlav los yog keeb kwm ntawm mob qog noj ntshav vim GH / IGF-1 muaj cov teebmeem mitogenic thiab tuaj yeem ua rau cov qog cell loj hlob.
** Kev pheej hmoo siab ntawm kev tsim txom: Feem ntau raug tsim txom los ntawm cov neeg ncaws pob lossis cov neeg nyiam kev tawm dag zog, uas ua rau muaj qhov tshwm sim loj xws li acromegaly (hauv cov neeg laus), teeb meem plawv, thiab lub cev loj.
Cov menyuam yaus: Kev loj hlob hormone deficiency (GHD), Turner syndrome, Prader-Willi syndrome, idiopathic luv stature (hauv qee lub tebchaws / cov lus qhia), kev loj hlob thiab kev loj hlob tsis zoo los ntawm lub raum tsis txaus, thiab lwm yam.
Cov neeg laus: Cov neeg laus uas muaj kev loj hlob hormone tsis txaus (feem ntau tshwm sim los ntawm kev phais qog pituitary, kev raug mob, kev kho hluav taws xob, thiab lwm yam), siv los txhim kho lub cev muaj pes tsawg leeg (cov leeg nce thiab rog poob), pob txha ntom, lipid metabolism, thiab lub neej zoo.
Daim Ntawv Qhia Kab Liab: Yuav tsum tau muab tshuaj los ntawm tus kws kho mob tshwj xeeb (endocrinologist, chaw kho mob loj hlob thiab kev loj hlob), thiab yuav tsum tau saib xyuas cov qib IGF-1, cov ntshav qabzib, cov thyroid ua haujlwm, kev kuaj mob, thiab lwm yam.
Contraindications: Paub cov qog malignant (tshwj xeeb yog cov qog hlwb), nquag proliferative retinopathy (mob ntshav qab zib), ua xua rau excipients; feem ntau tsis pom zoo rau cov poj niam cev xeeb tub.
Cov txheej txheem txhaj tshuaj: Feem ntau muab tshuaj subcutaneously ua ntej yuav mus pw txhua hmo (simulating physiological pulses), nrog rau qhov chaw txhaj tshuaj tig; tsis txhob muaj zog tshee thaum lub sij hawm reconstitution.
Kev pheej hmoo ntawm Kev Lag Luam Dub: "HGH 191aa" yuav los ntawm tsis yog- cov chaw kho mob feem ntau ua rau muaj kev pheej hmoo ntawm kev ua txhaum cai, kev kis kab mob, tsis muaj zog txaus, lossis kev ua phem rau lwm yam tshuaj (xws li insulin), ua rau muaj kev phom sij heev.
Endocrine Cornerstone Model: Cov cuab yeej cuab tam classic rau kev kawm pituitary - siab -IGF-1 axis, metabolic regulation, thiab aging mechanisms.
Kev Tshawb Fawb Txog Kev Noj Qab Haus Huv thiab Kev Laus: Siv los tshawb txog lub luag haujlwm ntawm kev loj hlob hormone hauv lipid metabolism, kev ua siab ntev ntawm cov leeg nqaij, thiab kev tiv thaiv neuroprotection (BDNF koom haum).
Pharmaceutical Process Benchmark: Raws li ib qho ntawm cov tshuaj protein ua ntej tshaj plaws los ua lag luam ntawm qhov loj siv cov tshuab DNA recombinant, nws cov lus qhia, folding, thiab purification txheej txheem nteg lub hauv paus rau biologics tom ntej (xws li insulin, interferon, thiab monoclonal antibodies).
Cim npe nrov: Peptide tshuaj HGH 191aa CAS No.: 12629-01-5, Tuam Tshoj Peptide tshuaj HGH 191aa CAS No.: 12629-01-5 manufacturers, lwm tus neeg, Hoobkas
