Adamax (N-acetyl-Semax-adamantane, sequence Ac-Met-Glu-Nws-Phe-Pro-Gly-Pro-adamantane) yog cov tsev neeg tsis zoo tshaj plaws thiab tsis tshua muaj siab. Muab rho tawm los ntawm ACTH(4-10) fragment, nws khaws cov tub ntxhais Semax caj qaum tab sis ntxiv ib qho adamantane tawb-zoo li pawg hydrophobic ntawm C-terminus thiab acetylated cap ntawm N{17}}terminus. Nyob rau hauv luv luv, nws coats ib tug me me peptide, uas yog yooj yim cleaved los ntawm peptidases, nrog adamantane raws li ib tug "lub tsho tiv thaiv mos txwv," tso cai rau nws kom muaj sia nyob ntev nyob rau hauv cov hlab ntsha thiab hla cov ntshav-hlwb barrier zoo dua. Tam sim no, nws tsis muaj kev pom zoo ua lag luam los ntawm ib lub chaw tswj hwm loj thoob ntiaj teb, thiab daim ntawv lo ib txwm nyeem "Kev Tshawb Fawb Siv Tsuas."
Adamax tus qauv tsim tshwj xeeb tshaj yog tias nws tseem ceeb "welds" ib pawg adamantane mus rau cov qauv Semax. Qhov no nruj, lipophilic tawb-zoo li cov qauv ua zoo li "lub tsho tiv thaiv mos txwv" rau peptide, tsis yog tsuas yog ua kom nws qhov kev tiv thaiv rau enzymatic degradation tab sis kuj tseem ua rau nws cov ntshav nce ntxiv - lub hlwb thaiv kev nkag mus. Hauv cov qauv kev tshawb fawb, nws tsis yog tsuas yog txhawb nqa qhov kev xav ntawm BDNF (lub hlwb- tau txais cov txiaj ntsig neurotrophic) thiab TrkB receptors tab sis kuj tswj cov tshuaj dopamine thiab norepinephrine. Kev paub txog kev txawj ntse thiab lub cev muaj zog txhawb nqa pom nyob rau hauv cov tsiaj sim, deb tshaj qhov zoo tib yam Semax, yog qhov zoo siab heev rau cov kws tshawb fawb ua cov kev tshawb fawb neuroprotective.
Feem ntau tus kab mob khaub thuas A hom yog ib txwm tiv taus rau cov kab mob tam sim no, thiab CDC tau ntev txij li tau tso tseg tsis pom zoo rau lawv ua ntej - kho kab mob. Central paj hlwb cov kev mob tshwm sim muaj teeb meem: insomnia, kiv taub hau, npau suav phem, ntxhov siab vim, chim siab; nyob rau hauv cov neeg laus, hallucinations thiab delirium feem ntau tshwm sim; ze li ntawm ib tug ntawm kaum tus neeg uas siv livedo reticularis ntev -lub sij hawm yuav tsim cov kab mob; thiab sudden edema, ua tsis taus pa luv, thiab qhov hnyav nce sai yog cov cim qhia ntawm lub plawv tsis ua hauj lwm latent . 95% yog tawm tsis hloov pauv hauv cov zis. Yog tias qhov koob tshuaj tsis txo qis vim muaj teeb meem rau lub raum, nws tuaj yeem sib sau thiab ua rau muaj tshuaj lom. Cov tshuaj ntshav siab tshaj 1.5-2.0 ug / mL tuaj yeem ua rau delirium thiab qaug dab peg. Tam sim ntawd nres PD kev kho mob yuav ua rau muaj kev rov zoo dua; gradual taper yog tsim nyog. Contraindicated nyob rau hauv cov neeg mob qaug dab peg, leej niam pub niam mis, thiab cov me nyuam hnub nyoog qis dua 1 xyoos.
Adamax yog rhiab heev rau qhov kub thiab txias. Nyob rau hauv daim ntawv lyophilized hmoov, nws yuav tsum tau khaws cia rau hauv lub freezer ntawm -20℃. Thaum rov ua dua nrog cov kab mob tua kab mob, nws yuav tsum tau hloov tam sim ntawd mus rau lub tub yees ntawm 2-8℃thiab tsuas yog khaws cia rau qhov siab tshaj plaws ntawm 1 mus rau 2 lub lis piam. Rov ua dua lub voj voog khov-thaw yuav tsum zam, vim tias cov qauv peptide tsis tuaj yeem tiv taus qhov kev ntxhov siab.
Cov kev ceev faj
PD: Pib koob tshuaj 100mg ib zaug lossis ob zaug ib hnub, koob tshuaj ntau tshaj 400mg / hnub; Antiviral: 200mg / hnub muab faib ua 1-2 koob tshuaj. Rau kev tiv thaiv kab mob khaub thuas hauv cov neeg mob uas muaj hnub nyoog tshaj 65 xyoos, txo qhov koob tshuaj ib nrab.
Qhov koob tshuaj kawg yuav tsum tau noj ua ntej 4 teev tsaus ntuj, txwv tsis pub, koj yuav tsaug zog txhua hmo.
Lub raum tsis txaus (tsawg CrCl) yuav tsum tau txo cov koob tshuaj raws li kev tshem tawm; nws tsis yog hais txog "noj ib ntsiav tshuaj tsawg," tab sis muaj peev xwm ib ntsiav tshuaj txhua hnub.
Kev siv ua ke nrog cov tshuaj anticholinergics, tricyclic antihistamines, phenothiazines, lossis antihistamines tuaj yeem ua kom lub qhov ncauj qhuav, tso zis, thiab hnov qab; kev siv ua ke nrog lub hauv nruab nrab lub paj hlwb stimulants (nrog rau cov tshuaj caffeine ntau) yuav ua rau qaug dab peg; haus cawv ob npaug rau kiv taub hau; alkaline zis (sodium bicarbonate, ntau cov khoom noj siv mis) tuaj yeem ua rau muaj tshuaj lom.
Tsis txhob tsav tsheb lossis nce ledges thaum noj cov tshuaj no; impaired concentration yog ib qho teeb meem loj.
Yog hais tias hallucinations, purpuric me ntsis, pob taws edema, ua tsis taus pa luv, kev nyuaj siab, los yog kev xav tua tus kheej tshwm sim, nres tshuaj thiab mus ntsib kws kho mob tam sim ntawd; tsis txhob tos rau "adaptation."
Cov tshuaj no yog contraindicated rau cov poj niam cev xeeb tub (Category C), leej niam pub niam mis, thiab cov menyuam yaus hnub nyoog qis dua 1 xyoos; cov neeg uas muaj keeb kwm ntawm qaug dab peg, congestive plawv tsis ua hauj lwm, glaucoma, los yog kab mob siab heev yuav tsum tau ua tib zoo soj ntsuam.
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