Epithalon (tseem hu ua Epitalon) yog ib qho tetrapeptide cais tawm ntawm bovine pineal gland extract hauv xyoo 1980 los ntawm xibfwb Khavinson ntawm lub koom haum ntawm Bioregulation thiab Gerontology hauv St. Petersburg, Russia. Nws cov amino acid sequence yog Ala-Glu-Asp-Gly. Nws yog ib feem ntawm lub cev pineal peptide Epithalamin thiab tom qab ntawd tau ua tiav tiav.
Nyob rau hauv luv luv, cov kws tshawb fawb nrhiav tau ib yam khoom nyob rau hauv lub caj pas pineal uas muaj peev xwm "rejuvenate cells," thiab Epithalon yog "cov khoom siv me tshaj plaws" ntawm cov khoom no. Nrog rau qhov hnyav molecular ntawm tsuas yog 390.35 Da, nws tuaj yeem khi rau qhov tshwj xeeb DNA sib lawv liag (ATTTC) thiab tswj cov noob qhia -ib qho tsis tshua muaj feat rau me me peptides.
Core Advantages thiab Functions
1. Telomerase Activation-"Kev Hloov mus rau Cell Lifespan"
Epithalon tuaj yeem tswj hwm hTERT mRNA kev qhia, qhib telomerase, thiab txuas ntxiv telomere ntev. Thawj zaug tshaj tawm los ntawm Khavinson hauv 2003, thiab nws tus kheej tau luam tawm thiab siv tau los ntawm Brunel University hauv 2025- nws txuas telomeres los ntawm qhov nruab nrab ntawm 33.3% hauv cov hlwb ib txwm. Qhov no yog lub hauv paus tseem ceeb rau nws lub npe hu ua "anti-aging peptide."
2. Restoring Circadian Rhythm-Tsis muaj Exogenous Melatonin
Nws tsis ncaj qha ntxiv melatonin, tab sis theej kho lub caj pas pineal lub peev xwm los ua ke melatonin. Cov kev tshawb fawb soj ntsuam pom tau tias kev tso zis ntawm 6-sulfo-melatonin nce 1.6 npaug hauv cov neeg laus, thiab kev qhia ntawm circadian atherosclerosis cov noob xws li Clock thiab Cry2 tau txhim kho zoo.
3. Antioxidant thiab DNA tiv thaiv
Nws txo cov tiam ntawm dawb radicals nyob rau hauv lub hlwb cov ntaub so ntswg, inhibits lipid peroxidation, thiab txo tus nqi ntawm chromosomal aberrations. Hauv cov nas aging nrawm (SAMP-1), Epithalon's DNA-tiv thaiv cov nyhuv tseem zoo tshaj rau melatonin.
4. Retinitis Pigmentosa-Ib qho teeb meem kev kho mob uas tsis tau xav txog
Kev sim tshuaj nrog 162 tus neeg mob uas muaj retinitis pigmentosa pom qhov kev txhim kho qhov nruab nrab ntawm qhov muag pom ntawm 0.15-0.20, qhov nthuav dav ntawm thaj tsam ntawm 90-120 degrees, thiab txo lossis ploj ntawm cov scotomas kiag li hauv 64.8% ntawm cov neeg mob. Tsis muaj qhov tshwm sim tsis zoo tshwm sim.
5. Tsiaj Lifespan Extension Data – Tab sis tsis txhob chim heev
Hauv CBA nas, pawg Epithalon, uas nyob rau 23 lub hlis, yog plaub zaug ntev dua li pawg tswj hwm; tus neeg nyob ntev tshaj plaws - nyob rau 34 lub hlis (piv rau 24 lub hlis hauv pawg tswj hwm). HER-2 / neu transgenic nas kuj pom tias muaj kev ncua ntev ntev. Txawm li cas los xij, nco ntsoov tias txhua qhov kev sim tsiaj tau ua los ntawm Khavinson pab neeg, thiab tsis muaj lub chaw kuaj mob ywj pheej tseem tau rov ua dua cov kev tshawb pom no.
Cia (Lyophilized Powder Reagent Diameter)
Unreconstituted lyophilized hmoov: -20 degree, kaw, tiv thaiv los ntawm lub teeb + desiccant, ruaj khov rau ntau dua los yog sib npaug rau 24 lub hlis; rau lub sijhawm ntev - khaws cia, khaws cia ntawm -80℃, uas tuaj yeem kav ntev li ob peb xyoos. Nws yog hygroscopic; N-terminal Glu yuav spontaneously cyclize rau hauv pyroglutamic acid, thiab cua sov thiab noo noo ua kom cov txheej txheem no.
Reconstituted: Dissolve nyob rau hauv sterile dej / BAC dej / physiological saline, 2-8 degree, tiv thaiv los ntawm lub teeb, thiab siv nyob rau hauv 14-30 hnub (conservatively, 2 lub lis piam yog lub sij hawm ruaj khov tshaj plaws); rau kev cia ntev dua, aliquot rau hauv ib zaug - siv ntim ntawm -80℃, tab sis tsis txhob rov qab khov-thaw cycles.
Ua ntej qhib, cia cov tshuaj sib npaug rau hauv chav sov li 15-20 feeb kom tsis txhob muaj qhov tsis zoo los ntawm kev nqus noo noo rau hauv lub raj mis thiab ua rau clumping.
Cov kev ceev faj
Ncuav dej maj mam nyob rau sab ntawm lub raj mis, zam vortexing -txawm hais tias cov tetrapeptide luv luv, nws Glu-Asp yog qhov tsis zoo, thiab lub zog shear tuaj yeem txhawb kev sib tw / sib sau. Cov tshuaj yuav tsum yog ntshiab thiab tsis muaj xim; Yog hais tias nws ua pos huab los yog flocculent, muab pov tseg tam sim ntawd.
Tsis txhob cia li saib "99% purity" rau COA: AEDG tsawg dhau lawm, thiab TFA / acetic acid counterion tuaj yeem dag 10-15% pom zoo. Kom tus neeg muag khoom lees paub LC-MS (M+H)⁺=391.1, HPLC dual- wavelength (215/280 nm), thiab cov ntaub ntawv endotoxin; txwv tsis pub, hauv kev sim ntawm tes, yog tias telomerase tsis qhib, koj yuav tsis tuaj yeem paub qhov txawv ntawm peptide puas lossis lub tshuab ua haujlwm tsis zoo.
Nws tsuas yog ib qho kev tshawb fawb RUO nkaus xwb, sau tias "Kev Tshawb Fawb Siv Tsuas, tsis yog rau tib neeg noj"; lub tsev kho mob Lavxias teb sab formulation yog txawv. Cov hmoov yuav nyob rau sab hnub poob tsis yog cov tshuaj raug cai; Nws ua tau circulates hauv lub cev ntawm IACUC.
Thaum ua haujlwm telomerase TRAP, kev tswj tsis zoo ntawm cov hlwb tsis muaj peptides thiab paub txog hTERT zoo tswj tau siv. Nyob rau hauv Khavinson cov ntaub ntawv nyoos, cov xov tooj ntawm tes thiab cov ntshav batch naj npawb yog qhov txawv txav; yam tsis tau kaw qhov xwm txheej, kev sib koom ua ke - CV yuav txaus ntshai.
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