Dermorphin yog ib qho polypeptide rho tawm ntawm daim tawv nqaij ntawm South American ntoo qav. Nws muaj kev sib raug zoo heev rau μ-opioid receptors, thiab nws cov nyhuv analgesic yog qhov zoo tshaj rau morphine.
Nws cov qauv molecular muaj D-hom amino acids, ua rau nws nyuaj rau cov enzymes hauv lub cev kom tawg, ua rau muaj kev cuam tshuam ntev -. Tam sim no, nws tsuas yog siv nyob rau hauv kev tshawb fawb pharmacological thiab tsis tau pom zoo rau kev kho mob formulation.
Nws yog kev tswj hwm opioid- ntsig txog peptide, uas ua rau muaj kev pheej hmoo ntawm kev quav tshuaj thiab ua pa nyuaj. Kev siv tsis raug cai hauv kev sib tw xws li kev sib tw nees yog txwv tsis pub, thiab nws txoj kev txhaj tshuaj rau tib neeg yog txwv.
Core Functions:
Muaj peev xwm Central Analgesia: Siab affinity rau μ-opioid receptors → Inhibition ntawm adenylate cyclase, kaw cov calcium channels, qhib cov poov tshuaj raws → Hyperpolarization ntawm mob neurons, thaiv qhov mob ascending kis nyob rau hauv lub dorsal horn ntawm tus txha caj qaum thiab lub aqueduct ntawm lub procingno midbrain,
Opioid Receptor Research Tool: Raws li ib qho classic ntshiab μ- xaiv ligand, nws yog siv rau MOR radioligand khi, tshuaj ntsuam xyuas kev ua tau zoo, thiab kev tshawb fawb ntawm opioid kam rau ua / kev quav tshuaj.
Cov txiaj ntsig tseem ceeb:
Tsawg Tolerance thiab Addiction Risk: Txawm hais tias nws cov txiaj ntsig muaj zog, nws ua rau muaj kev pheej hmoo tsawg dua ntawm kev tsim cov tshuaj tiv thaiv thiab kev cia siab rau lub cev (kev quav yeeb quav tshuaj) piv rau cov tshuaj morphine - zoo li tshuaj.
Muaj zog tiv taus rau Enzymatic degradation: Vim tias nws muaj ib qho tshwj xeeb D-alanine (D-Ala), nws nyuaj rau cov enzymes hauv tib neeg lub cev kom degrade, ua rau lub sijhawm ntev heev ntawm kev ua hauv lub cev.
Tsis tshua muaj siab Receptor Selectivity: Nws muaj affinity siab heev rau μ-opioid receptors thiab tsis tshua muaj affinity rau δ thiab κ receptors, ua rau nws yog ib qho zoo tagnrho kev sojntsuam rau kev kawm opioid receptor mechanisms.
Dermorphin yog ib qho tshuaj polypeptide uas muaj feem cuam tshuam rau kev degradation thiab inactivation yog tias tsis khaws cia zoo. Cov xwm txheej tshwj xeeb yog raws li hauv qab no:
Kev cia khoom:
Powder State (Long-Lub Sij Hawm): Yuav tsum tau kaw, tiv thaiv lub teeb, thiab khaws cia rau hauv qhov chaw khov ntawm -20℃lossis -80 degree. Raws li cov xwm txheej no, nws feem ntau tuaj yeem khaws cia rau 1 txog 3 xyoos.
Kev daws teeb meem hauv xeev (Lub Sijhawm luv-): Thaum yaj, nws muaj kev cuam tshuam rau kev degradation. Nws raug nquahu kom aliquot rau hauv ib zaug - siv tshuaj me me. Nws tuaj yeem khaws cia rau kwv yees li 6 lub hlis ntawm -80℃thiab tsuas yog kwv yees li 1 lub hlis ntawm -20 degree.
Absolute Contraindications: Strictly avoid repeated freeze-thaw cycles (usually no more than 3 times), and avoid high temperatures (>25 degree) thiab muaj zog lub teeb raug.
Kev ceev faj rau kev siv: Cov khoom no yog cov muaj zog opioid peptide nrog cov khoom muaj zog ntxiv. Kev noj tshuaj ntau dhau tuaj yeem ua rau ua pa. Nws yuav tsum tsis txhob noj los yog txhaj rau tib neeg.
Hnav hnab looj tes thiab tsom iav thaum tuav. Tsis txhob kov cov tawv nqaij ncaj qha thiab nqus tau cov hmoov. Yog hais tias nws los rau hauv daim tawv nqaij, yaug tam sim ntawd nrog dej.
Rau kev siv tsuas yog nyob rau hauv qhov chaw kuaj tshuaj raug cai tshawb fawb tshuaj. Nws yog txwv tsis pub siv rau cov tsiaj sib tw xws li racehorses. Kev siv tsis raug cai thiab kev faib tawm yog txhaum cai.
Siv cov tshuaj tsis huv rau kev sib cais, tsis txhob muaj cov kua qaub lossis alkaline ib puag ncig. Cov tshuaj diluted yuav tsum tsis txhob khaws cia rau lub sijhawm ntev.
Tshem tawm cov kev sim pov tseg cov kua thiab cov hmoov seem uas yog cov tshuaj tswj tau. Tsis txhob muab pov tseg los yog pov tseg lawv arbitrarily.
Yuav Order li cas?
Ua ntej, thov qhia peb txog koj qhov kev xav tau lossis daim ntawv thov scenario.
Thib ob, peb yuav muab cov lus hais raws li koj xav tau lossis peb cov lus qhia.
Thib peb, tus neeg siv khoom lees paub cov qauv thiab them tus nqi tso nyiaj.
Plaub, peb muaj lub luag haujlwm rau kev npaj ntau lawm. Cov luv nqi muaj rau kev txiav txim ntau.
Koj cov khoom zoo li cas? Ua ntej, peb cov khoom zoo yog zoo heev thiab zoo ib yam. Peb ua 100% kuaj ua ntej xa zaub mov.
Yog li ntawd, peb siv kev tswj xyuas nruj ua ntej ua zaub mov xa tuaj. Yog tias muaj teeb meem zoo tau pom los ntawm peb, peb yuav hloov cov khoom dawb los yog muab cov nyiaj rov qab.
Yuav ua li cas thiaj tsim tau lub sijhawm ntev -, kev koom tes zoo nrog peb?
1. Peb hais kom muab siab - cov khoom zoo thiab cov nqi sib tw kom ntseeg tau cov neeg siv khoom zoo;
2. Peb hwm txhua tus neeg siv khoom, saib lawv li phooj ywg, thiab ua siab dawb ua lag luam thiab ua phooj ywg nrog lawv, txawm lawv tuaj qhov twg los.
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