Cortagen (AEDP, Ala-Glu-Asp-Pro) yog tetrapeptide los ntawm Khavinson's St. Petersburg kab, tsom rau lub hlwb cortex. Nws muaj qhov hnyav molecular ntawm 430.4 Da thiab cov lej CAS feem ntau yog 152796-48-4 / 335591-03-2 (tus lej sib txawv nyob ntawm qhov chaw). Nws yog synthesized los ntawm thim rov qab engineering los ntawm cov amino acid profile ntawm Cortexin, ib qho extract los ntawm bovine cerebral cortex. Nws txawv ntawm Epitalon (AEDG) tsuas yog los ntawm kev hloov C-terminal Pro nrog Gly - ib kauj ruam no hloov cov ntaub so ntswg tsom los ntawm pineal caj pas / telomere axis mus rau cov neurons thiab glial hlwb ntawm lub paj hlwb cortex.
Cov haujlwm tseem ceeb tshawb fawb
Cortagen, vam khom rau nws qhov tshwj xeeb cortical - tsom rau kev tswj hwm epigenetic, tsim ib qho peb - hauv - ib qho kev ua haujlwm ntawm neuroprotection, regenerative kho, thiab homeostasis regulation, npog txhua qhov ntev ntawm kev tshawb fawb scenarios ntsig txog lub hauv paus paj hlwb raug mob thiab kev laus:
1. 1. **Cortical Neuroepithelial Kho:** Qhov kev ua haujlwm no loosens tshaj -cov ntsiab lus neural chromatin thaum muaj hnub nyoog, rov pib dua cov ntawv sau ntawm cov noob caj noob ces, rov pib dua cov noob qhia txog kev laus ntawm cov neurons, ncua kev ua haujlwm poob qis hauv cortical neurons, thiab thim rov qab hom kev laus ntawm cov hlwb.
2. **Neural Plasticity Remodeling:** Qhov kev ua haujlwm no upregulates cov kev qhia ntawm core neurotrophic yam xws li BDNF thiab NGF, txhawb dendritic spine proliferation thiab synaptic qauv stability, txhim khu synaptic teeb liab kis efficiency, thiab pab txhawb cortical neural network reconstruction. Nws yog feem ntau siv hauv kev tshawb fawb txog cov txheej txheem ntsig txog kev paub, nco, thiab neural conduction.
3. **Central Stress Resilience thiab Neuroprotection:** Qhov kev ua haujlwm no ua tau zoo tshem tawm cov pa oxygen ntau dhau hauv cov neurons, ua kom cov kab mob endogenous cellular antioxidant, antagonizes excitotoxic puas thiab ischemia-reperfusion raug mob, inhibits txawv txav apoptosis ntawm cortical neurons, thiab ntxiv dag zog rau cov ciaj sia taus.
4. **Anti-Kev Tiv Thaiv Homeostasis Txoj Cai ntawm Neural Microenvironment:** Txoj haujlwm no tau xaiv ntau dua -activated inflammatory pathways nyob rau hauv lub hauv paus paj hlwb, downregulates tso tawm pro-inflammatory mediators, blocks persistent neurological kev puas tsuaj los ntawm kev tsis zoo nyob rau hauv lub paj hlwb, - o-kev paub tsis meej nyob nruab nrab.
5. Peripheral Nerve Repair Enhancement: Nws tuaj yeem ua kom cov txheej txheem myelination ntawm cov paj hlwb puas, txhim kho tus nqi rov tsim dua tshiab thiab cov teeb liab transduction tshaj tawm ntawm cov paj hlwb, thiab muab qhov kev cuam tshuam tshiab rau kev kho mob peripheral paj hlwb thiab kev tshawb fawb txog kev raug mob neuropathological.
Core Zoo
Cov tetrapeptide yog dawb ntawm Met, Cys, thiab disulfide daim ntawv cog lus, ua rau nws tiv taus lyophilization thiab hydrolysis ntau dua li BPC/TB-zoo li peptides ntev; piv rau Cortexin (ib qho sib xyaw polypeptide muab rho tawm los ntawm tsiaj lub hlwb), nws muaj ib qho, qhov tseeb ib ntus, tseem tsis hloov pauv ntawm cov khoom siv, thiab tso cai rau cov qauv tsim dua tshiab - kev tshawb fawb ua haujlwm; piv rau Pinealon, nws tsom rau kev tsim dua tshiab thiab tsim synapse, tsis cuam tshuam rau pineal axis; Nws tsim cov teeb liab ntawm cov koob tshuaj tsawg heev (nM hauv cov hlwb, 0.1-10 ug / kg hauv cov tsiaj), zam ib qho ntawm cov tshuaj pharmacological ntawm sympathetic / choline / glutamate, thiab theoretically tsis sib tw nrog cov pa neuropharmaceuticals rau cov metabolism. Nws lub peev xwm los tswj nws cov txiaj ntsig hauv cov laus cortical kab lis kev cai yog ib qho tseem ceeb muag taw tes piv rau peptides uas "teb tsuas yog hauv cov ntaub so ntswg hluas xwb."
Standard Storage Conditions
Cortagen lyophilized tetrapeptides yog rhiab heev rau oxidation, kub thiab av noo hloov pauv, thiab lub teeb raug. Ib puag ncig tsis zoo tuaj yeem cuam tshuam ncaj qha rau cov saw peptide txoj haujlwm nucleobinding thiab ua rau nws muaj peev xwm tswj hwm chromatin. Kev khaws cia nruj nruj yuav tsum tau:
1. Unopened lyophilized hmoov: Khaws rau hauv qhov chaw kaw, lub teeb - pov thawj, qhuav, thiab ya raws - pov thawj ib puag ncig. ruaj khov cia rau 12 lub hlis ntawm qhov kub thiab txias ntawm -20 degree; cia ntawm -80℃hauv ib puag ncig kaw, lub teeb-pov thawj tuaj yeem txuas lub txee lub neej mus rau 24 lub hlis. Kev rov ua kom khov-thaw cycles thiab ntev raug rau hauv chav tsev kub yog nruj me ntsis txwv.
2. Reconstituted kua system: yuav tsum tau aliquoted rau ib zaug - sim siv kom tsis txhob oxidation poob los ntawm rov qhib dua. Khaws rau 6 lub hlis ntawm -80℃hauv lub kaw lus, lub teeb- pov thawj ib puag ncig; tsuas yog tsim rau lub sijhawm luv luv cia (hauv 1 lub hlis) ntawm -20℃. Lub tub yees ntawm 4℃thiab cia nyob rau hauv chav tsev kub yog txwv tsis pub.
3. Kev Ua Haujlwm Ib puag ncig yuav tsum tau ua: qhib thiab kho dua tshiab yuav tsum tau ua sai sai hauv qhov qis- qhov kub thiab txias, ib puag ncig qhuav kom txo cov hmoov sib cuag nrog cov dej noo thiab oxygen. Siv sterile, enzyme-dawb ultrapure dej rau reconstitution thaum twg los tau. Khaws kom deb ntawm lub teeb muaj zog thiab muaj zog oxidants. Turbidity los yog nag lossis daus qhia peptide degradation, thiab cov tshuaj yuav tsum muab pov tseg tam sim ntawd.
Yog tias Cortagen's epigenetic regulatory mechanisms tiag tiag muaj nyob rau hauv vivo, lub sij hawm ntev - lom tshwm sim ntawm nws cov gene qhia remodeling-suav nrog muaj peev xwm ntsiag to ntawm qog suppressor yam los yog desuppression ntawm proto-oncogenes- tsis tau muaj txaus nyob rau hauv kev tshawb fawb tsiaj. Saib Cortagen raws li "kev kho mob" rau kev paub txog kev poob qis lossis kev puas hlwb puas yog ob qho tib si kev txhais lus ntawm cov pov thawj uas twb muaj lawm thiab ua kom yooj yim ntawm biology ntawm cov kab mob nyuaj. Nws lub luag haujlwm tseem ceeb tshaj plaws tam sim no yog qhov kev tshawb nrhiav molecule nrog ib qho kev xav tsis thoob, cov ntaub ntawv qhia ua ntej, tab sis tsis muaj pov thawj rau tib neeg txhais lus.
Cim npe nrov: 99% purity, Hoobkas -customized cortagen peptide. cas: 335591-03-2, Tuam Tshoj 99% purity, Hoobkas-customized cortagen peptide. cas: 335591-03-2 manufacturers, lwm tus neeg, Hoobkas
