Mechanism ntawm Action
2.1 Dual Site of Action
GHRP-6's GH- tso tawm cov nyhuv ua haujlwm ntawm ob theem pituitary thiab hypothalamic. Kev tshawb fawb soj ntsuam los ntawm Popovic et al. paub tseeb tias nyob rau hauv cov neeg mob uas muaj hypothalamic-pituitary disconnection, GH cov lus teb rau GHRP-6 tau thaiv tag nrho, thaum cov lus teb rau GHRH tseem zoo li qub; Thaum muab tshuaj ua ke, cov nyhuv synergistic ntawm GHRP-6 thiab GHRH ploj mus, pom tsuas yog cov txiaj ntsig kev lej lej. Qhov kev tshwm sim no qhia ncaj qha tias thawj qhov chaw ntawm kev ua ntawm GHRP-6 yog nyob rau ntawm theem hypothalamic, ua kom tsis muaj zog ntawm GH mem tes los ntawm kev txo qis qhov cuam tshuam ntawm somatostatin ntawm lub caj pas pituitary.
2.2 Synergistic Amplification nrog GHRH
GHRP-6 thiab GHRH ua raws li txoj hauv kev sib txawv, ua kom muaj txiaj ntsig zoo tshaj - ntxiv thaum siv ua ke. Hauv cov kev kawm ib txwm muaj, AUC ntawm GH secretion yog 483.7 ± 99.2 ug / L / 120 min thaum GHRH siv ib leeg, thiab 1434.8 ± 393.0 thaum GHRP-6 siv ib leeg. Qhov sib xyaw ua ke AUC tau mus txog 3771.5 ± 399.6, ntau dua li cov lej lej ntawm kev tswj hwm tshuaj ib leeg.
2.3 GH- txoj hauv kev tiv thaiv cell ywj siab
Ntxiv nrog rau GHS-R1a, GHRP-6 tuaj yeem khi rau CD36 scavenger receptor, kho cov teebmeem pleiotropic tiv thaiv tsis muaj zog ntawm GH axis. Txoj kev no ua rau lub PI-3K/AKT1 cascade thiab induces hypoxia-inducible factor-1 (HIF-1), koom nrog hauv cell survival; nws kuj upregulates PPAR thiab downregulates TGF- 1, CTGF, thiab PDGF, exerting anti-fibrotic teebmeem; thiab nws blocks downstream inflammatory cascades los ntawm inhibiting NFκB qhia thiab ua kom.
2.4 Zoo Inotropic Mechanism
Hauv cardiomyocytes thiab cais lub siab lub ntsws, GHRP-6 nce Ca²⁺ nkag mus rau hauv qhov hluav taws xob-gated calcium raws ntawm PLC / DAG / PKC txoj hauv kev, ua rau Ca²⁺ tso tawm los ntawm sarcoplasmic reticulum, tsim cov lus teb zoo inotropic yam tsis muaj lub plawv dhia. Intravenous bolus txhaj ntawm 400 ug / kg nce ejection feem los ntawm 15% -20% nyob rau hauv noj qab haus huv thiab infarcted luav qauv.
GH tso Kinetics
Qhov koob tshuaj saturation ntawm GHRP-6 yog kwv yees li 1 mcg/kg. Hauv qab qhov pib no, GH tso tawm nce ntxiv hauv koob tshuaj - nyob ntawm seb; saum toj no cov koob tshuaj no, ib tug toj siab yog mus txog, thiab ntxiv tsub kom tsis txhob nce GH secretion, tsuas yog amplifying kev phiv xws li cortisol, prolactin, thiab qab los noj mov. Tom qab ib qho kev txhaj tshuaj subcutaneous, plasma GH nce siab hauv 15-30 feeb, nrog ib nrab-lub neej ntawm kwv yees li 20-30 feeb, thiab qhov siab GH yuav kav li ntawm 2-3 teev.
Cov lus qhia rau kev siv
Dosage Parameters
Rooj
Yam Khoom
Txoj kev tswj hwm
Kev txhaj tshuaj subcutaneous (nyiam dua) lossis txhaj tshuaj intramuscular
Ib koob
100 mcg (kwv yees li 1 mcg / kg saturation koob)
Dosage zaus
2-3 zaug hauv ib hnub, Ntau dua lossis sib npaug li 3 teev sib nrug
Hnub tim ntawm Thawj Tswj Hwm
Fasting State (ntau tshaj 2 teev tom qab noj mov)
Lub Sijhawm Pom Zoo
Thaum sawv ntxov ntawm lub plab khoob, tom qab kev cob qhia, ua ntej yuav mus pw
Siv sijhawm ntev
8-12 lub lis piam, qee qhov kev kho mob yuav ncua mus rau 16 lub lis piam
Chaw txhaj tshuaj
Lub plab, anterolateral ncej puab, posterior sab caj npab (alternating)
Reconstitution thiab Dosage Conversion
Rov ua dua cov hmoov lyophilized nrog cov dej tsis huv rau kev txhaj tshuaj lossis dej tshuaj tua kab mob uas muaj benzyl cawv. Piv txwv li, ntxiv 2.5 mL ntawm cov tshuaj tua kab mob rau hauv 5 mg vial ua rau muaj qhov concentration ntawm 2 mg / mL (ie, 2000 mcg / mL). Thaum siv cov tshuaj insulin U-100:
100 mcg=0.05 mL=5 units
200 mcg=0.10 mL=10 units
Kev sib koom ua ke
Thaum siv ua ke nrog GHRH analog (xws li CJC-1295 Tsis muaj DAC / Mod GRF 1-29), ob qho tib si tuaj yeem ua haujlwm ib txhij hauv tib lub tshuaj. Ib qho kev sib xyaw ua ke yog GHRP-6 100 mcg + CJC-1295 100 mcg, siv qhov sib xyaw ua ke ntawm GH mem tes los ntawm ob txoj hauv kev ntawm GHS-R1a thiab GHRH-R.
Daim ntawv thov Scenario
Kev kuaj mob
GHRP-6 tuaj yeem siv los ua GH stimulation test tshuaj los ntsuas pituitary GH cia ua haujlwm los ntawm kev tswj hwm ib leeg. Daim ntawv thov no ua raws tib txoj hauv kev raws li daim ntawv thov kuaj mob ntawm GHRP-2 (Pralmorelin).
Kev tiv thaiv kab mob plawv
Ib txoj kev tshawb fawb keeb kwm xyoo 2003 los ntawm Merck Research Laboratory tau qhia tias nyob rau hauv cov qauv canine ntawm dilated cardiomyopathy, 21 hnub ntawm kev kho mob ntev nrog GHRP-6 tau ua rau 0% sai sai tuag tus nqi tom qab mob myocardial infarction, piv rau kwv yees li 50% hauv pawg tsheb thiab pawg GH{7. Cov txheej txheem cuam tshuam nrog kev txhawb nqa kev ua haujlwm hauv cov uas tsis yog-ischemic myocardium, khaws cia cov tshuaj tiv thaiv antioxidant, thiab txo qis ntawm ROS tiam.
Multi-Ischemia/Reperfusion Protection tiv thaiv lub cev
Hauv cov qauv nas ntawm daim siab ischemia/reperfusion, pharmacological pretreatment nrog GHRP-6 ua rau lub siab puas tsuaj thiab txo cov kab mob hauv nruab nrog cev (lub ntsws, lub raum, txoj hnyuv me), nrog rau mob ua pa nyuaj siab{4}}xws li mob ntsws hloov, transmural plab hnyuv infarction, thiab crosis. Qhov kev ua haujlwm cytoprotective no tau cuam tshuam nrog ROS tiam attenuation, khaws cia ntawm cov tshuaj tiv thaiv antioxidant, thiab txo cov kev ua ntawm myeloperoxidase, qhia txog lub peev xwm ntawm GHRP-6 hauv kev tswj cov mob ischemia / reperfusion thiab poob siab ntsig txog cov kab mob inflammatory teb (SIRS).
Anti -fibrosis
GHRP-6 downregulates TGF- 1 thiab CTGF qhia los ntawm PPAR -driven cascade, txo cov collagen thiab extracellular matrix protein deposition nyob rau hauv cov tsiaj qauv ntawm cirrhosis thiab proliferative caws pliav.
Kev txhawb nqa zaub mov thiab cachexia
GHRP-6 yog qhov qab los noj mov tshaj plaws- txhawb cov tswv cuab ntawm GHRP tsev neeg, ua rau muaj kev xav tshaib plab tsis pub dhau 15-20 feeb tom qab txhaj tshuaj vim nws cov ghrelin-mimicking effect. Cov yam ntxwv no ua rau nws muaj txiaj ntsig tshwj xeeb hauv kev tshawb fawb txog kev noj zaub mov kom tsis muaj rog, nkim kab mob, thiab mob qog noj ntshav cachexia.
Kev tiv thaiv cov leeg
Zoo ib yam li GHRP-2, GHRP-6 ncaj qha inhibits kev qhia ntawm dexamethasone-induced enzymes tseem ceeb ntawm cov leeg nqaij atrophy, Atrogin-1 thiab MuRF1, ntawm GHS-R1a, exerting ib leeg-tiv thaiv cov leeg tsis muaj IGF-1 transcriptional upregulation.
Kho ntaub so ntswg
Kev sib xyaw ua ke ntawm GHRP-6 thiab EGF tau pom tias muaj kev sib koom ua ke ntawm cov tsiaj ua qauv ntawm ntau yam sclerosis, peripheral axonal lesions, thiab cerebral ischemia, muab cov pov thawj kev sim rau nws daim ntawv thov hauv cov kab mob neurodegenerative.
FAQ
Q: Qhov kev txiav txim yam tsawg kawg nkaus yog dab tsi?
A: Yam tsawg kawg nkaus kom muaj nuj nqis yog 10 fwj / teeb.
Q: Nws siv sijhawm ntev npaum li cas rau nkoj?
A: Hauv - cov khoom xaj yuav raug xa tuaj hauv 24 teev.
Q: Dab tsi purity koj tuaj yeem muab tau?
A: Txheem purity 99%.
Q: Qhov kev pabcuam courier koj siv?
A: FedEx, DHL, UPS, thiab kev pabcuam xa ntawv muaj.
Q: Ntev npaum li cas shipping?
A: Kwv yees li 10-15 hnub.
Q: Koj puas tuaj yeem muab daim ntawv tshaj tawm COA (Copyright Account) thiab HPLC (High{0}}Performance Computing) qhia?
A: Yog lawm, tag nrho cov khoom raug kuaj xyuas ua ntej ua zaub mov xa tuaj.
Q: Koj puas txhawb OEM / ODM?
A: Kev pabcuam OEM / ODM tau txais kev txhawb nqa, ua raws li qhov yuav tsum tau ua kom tsawg kawg nkaus.
Q: Yuav ua li cas tom qab - cov kev pab cuam muag khoom?
A: Tom qab cov neeg siv khoom kos npe rau cov khoom, yog tias qhov teeb meem zoo tau lees paub los ntawm peb cov khoom, lawv tuaj yeem txaus siab rau kev hloov pauv dawb lossis nyiaj rov qab. Peb ua raws li lub hauv paus ntsiab lus kev pab cuam ntawm pragmatism thiab lub luag hauj lwm, nquag teb thiab tswj txhua yam teeb meem, tsis muaj shirking lub luag hauj lwm los yog zam teeb meem, thiab ua peb zoo tshaj plaws los tiv thaiv cov cai thiab kev txaus siab ntawm peb cov neeg muas zaub.
Q: Txoj kev them nyiaj twg muaj?
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