VIP yog 28-amino acid endogenous neuropeptide ib txwm muaj nyob rau hauv lub cev, feem ntau faib rau hauv lub ntsws, kab mob plawv, thiab hauv nruab nrab paj hlwb. Nws qhov muag khoom loj tshaj plaws yog nws cov nyhuv "peb-hauv-ib": nws muaj zog ua kom cov hlab ntsha thiab cov hlab ntsws pulmonary, txo qhov mob, thiab tiv thaiv cov hlab ntsha.
Core Zoo
Nws muaj qhov tsis tshua muaj kev sib xyaw ua ke ntawm "broad-spectrum anti-inflammatory + vasodilatory + moos- tswj" cov teebmeem ntawm endogenous neuro-immune-vascular triple messengers. VIP muaj kev faib dav dav, ncav cuag lub plab, lub ntsws, lub cev tiv thaiv kab mob, thiab SCN.
Nws ua ntau dua li "kev rov pib dua lub cev" dua li kev tawm tsam ntau dua li ib zaug - lub hom phiaj tiv thaiv kab mob peptide; Cov teeb liab tau pom hauv cov qauv tsiaj rau RA, EAE, IBD, thiab MASH.
Nws muaj cov khoom siv hluavtaws, aviptadil (ib qho isnuclear molecule), uas tau dhau los ntawm EUA thiab PAH kev sim nqus pa rau COVID-19 ARDS, muab pov thawj ntau rau tib neeg siv dua li RUO peptides ntshiab (txawm hais tias nws yog qhov kawg tsis pom zoo).
Qhov tseem ceeb Disadvantages:
Nrog ib nrab ntawm -lub neej ntawm 1–2 feeb, liab qab peptide SC yog qhov tseem ceeb tau noj los ntawm cov enzymes hauv zos, xav tau cov tshuaj tsuag qhov ntswg, ua pa, nqus IV tas li, lossis lipo- lossis fused formulations (pemziviptadil/PB1046) kom ua tau zoo.
Tib neeg cov pov thawj muaj tsawg thiab sib xyaw: PAH nqus pa thiab sarcoidosis nasal spray tau pom cov txiaj ntsig zoo me me; qhov tseem ceeb ntawm COVID kev sim ntawm aviptadil raug tso tseg vim tsis muaj txiaj ntsig; Lub Shoemaker CIRS qhov ntswg tsuag raws tu qauv yog kev soj ntsuam, tsis yog RCT.
Cov nyhuv liab qab vasodilatory muaj zog heev -IV nqus tau tuaj yeem ua rau dej ntws, orthostatic hypotension, tachycardia, thiab cov quav dej; tus kheej- kev tswj hwm hauv chaw kho mob sab nraud zoo li caij cov ntshav siab rollercoaster.
Cov npoo kev nyab xeeb rau ntev -lub sij hawm exogenous VIP elevation (VIPoma, txawm hais tias muaj kev tswj hwm, qhia txog thaj tsam grey ntawm kev zais / electrolytes) tsis nkag siab tag nrho; nws tsis pom zoo thiab poob rau hauv thaj tsam grey ntawm RUO / cov chaw muag tshuaj.
Kev cia khoom:
VIP yog peptide, thiab pH heev heev - peptide rhiab heev.
Nyob rau hauv daim ntawv lyophilized hmoov, khaws cia, tiv thaiv los ntawm lub teeb thiab noo noo. Rau ntev - khaws cia ntev, cia li khaws cia ntawm -20℃. Rau luv luv - siv sij hawm, lub tub yees (2-8 degree) raug pom zoo. Tsis txhob khaws cia rau hauv ib puag ncig alkaline-nws yuav degrade tag nrho hauv cov tshuaj nrog pH ntawm 13 hauv 30 feeb. Nruab nrab rau me ntsis acidic ib puag ncig (pH tsawg dua lossis sib npaug rau 7) yog nws qhov kev pom zoo.
Nws dhau los ua qhov muag heev tom qab kev tsim kho dua tshiab. Cov kev tshawb fawb qhia tias nws degrades txawm nyob rau hauv tub yees ntawm tsawg concentrations, yog li siv nws sai li sai tau tom qab reconstitution. Thaum npaj cov tshuaj, siv cov dej tsis huv los yog cov tshuaj tsis haum (pH 6-7), maj mam hliv cov dej nyob rau sab ntawm lub raj mis thiab maj mam sib tov. Tsis txhob tshee hnyo. Rov qab khov-thaw cycles raug txwv nruj heev; ib zaug khov-thaw lub voj voog yuav rhuav tshem cov qauv.
Cov kev ceev faj:
Thaum kawg, lub ntsiab lus tseem ceeb: VIP cov khoom muaj nyob rau hauv kev ua lag luam feem ntau yog lyophilized hmoov. Cov no yog nruj me ntsis txwv rau siv nyob rau hauv kev tswj xyuas ib puag ncig. Tsis txhob kho lawv li cov khoom siv zoo tib yam lossis cov khoom siv kho mob. Tsis tas li ntawd, yog tias koj tab tom ua cov kev sim cuam tshuam, nco ntsoov sab laj cov ntaub ntawv tshawb fawb tshiab tshaj plaws rau cov kev tshawb fawb tshwj xeeb; tsis txhob cia siab rau kev kwv yees.