● Cov yam ntxwv tseem ceeb: IGF-DES yog ib qho kev sib piv ntawm cov tshuaj hormones ntuj insulin-zoo li kev loj hlob zoo-1 (IGF-1). Tshwj xeeb, nws tsis muaj thawj peb cov amino acids (N-terminal tripeptide: glycine-proline-glutamate) ntawm tag nrho-ntev IGF-1 molecule. Qhov kev hloov kho no tsis muaj nyob hauv tib neeg lub cev.
● Keeb Kwm: Nws tshwm sim los ntawm kev tshawb fawb ntawm cov qauv- kev sib raug zoo ntawm IGF-1. Cov kws tshawb fawb pom tau tias tshem tawm thawj peb cov amino acids cuam tshuam kev cuam tshuam ntawm cov peptide no thiab nws cov protein khi.
●Qhov txawv ntawm IGF-1: Tag nrho-ntev IGF-1, thaum ncig hauv cov ntshav, feem ntau (tshaj 99%) khi rau IGF-binding protein (IGFBP) tsev neeg. Qhov kev khi no ruaj khov IGF-1 tab sis tseem txwv tsis pub nws cov bioavailability thiab potency ntawm cov ntaub so ntswg, ua raws li kev khaws cia thiab kev tswj hwm.
●"DES" Advantage (Theoretical): Tshem tawm thawj peb cov amino acids txo qhov kev sib raug zoo ntawm IGF-DES rau feem ntau IGFBPs, tshwj xeeb tshaj yog cov cab kuj tseem ceeb IGFBP-3. Raws li txoj cai, qhov no yuav ua rau:
○ Ib qho piv txwv pub dawb ntau ntxiv: IGF-DES muaj feem ntau dua ntawm cov khoom siv roj ntsha, tsis muaj kev cuam tshuam ("dawb") piv rau IGF-1.
○ Kev ua kom muaj roj ntsha muaj zog: Nws ntseeg tau tias qhov no ntau dua qhov pub dawb, ntawm cov molar concentrations, tuaj yeem txhim kho receptor activation potency hauv cov ntaub so ntswg xws li cov leeg nqaij thiab pob txha mos piv rau IGF-1. Cov kev tshawb fawb tau pom tias nws lub zog yuav yog 10-100 npaug ntawm IGF-1 hauv vitro thiab hauv qee cov qauv tsiaj.
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