Peptide synthesis yog hais txog cov txheej txheem ntawm kev sib txuas cov amino acids nyob rau hauv ib qho kev sib lawv liag los tsim ib cov saw hlau polypeptide. Txoj kev ua haujlwm tseem ceeb tshaj plaws yog cov khoom siv -theem synthesis, cov txheej txheem pioneer los ntawm Bruce Merrifield hauv 1963, uas nws tau txais 1984 Nobel nqi zog hauv Chemistry. Lub hauv paus ntsiab lus yog anchoring carboxyl terminus ntawm thawj amino acid rau ib qho insoluble resin; Tom qab cov amino acids yog tom qab ntawd ntxiv los ntawm C-terminus mus rau N-terminus los ntawm kev rov ua dua lub voj voog ntawm kev tiv thaiv, kev ua kom, thiab cov kauj ruam sib txuas, ua tiav hauv qhov kev sib cais ntawm lub hom phiaj peptide los ntawm cov cob.
Txoj kev no ua kom yooj yim rau cov txheej txheem purification thiab yooj yim amenable rau automation, yog li tsim nws tus kheej raws li ib tug txheej txheem rau cov synthesis ntawm luv luv - mus rau - nruab nrab - ntev peptides. Peptide synthesis tuav cov txiaj ntsig tseem ceeb thoob plaws ntau qhov chaw, suav nrog kev tshawb fawb thiab kev tsim kho tshuaj, kev tshawb nrhiav kev ua haujlwm lom neeg, thiab tsim tshuaj tiv thaiv.