Adamax yog kev tshawb fawb hluavtaws peptide hloov nrog pawg adamantyl raws li Semax (ACTH₄₋₁₀ analogue). Qhov kev hloov kho no yog txhawm rau txhim kho lipophilicity thiab ntshav - lub hlwb thaiv kev nkag mus rau hauv lub hlwb, thiab nws tau kawm hauv kev tshawb fawb teb raws li nootropic peptide. Txawm li cas los xij, nws qhov kev siv tsis tau yog los ntawm peb qhov tseem ceeb: cov tshuaj pharmacological contraindications tau los ntawm adamane (cov qauv tsim nyog rau cov tshuaj pom zoo xws li amantadine thiab memantine), qhov xwm txheej thiab qib ntawm cov pov thawj (kev tsis ncaj qha extrapolation raws li kev tshawb fawb Semax), thiab cov yam ntxwv ntawm kev tshawb fawb - qib tshuaj (tsis muaj kev tswj hwm).
Raws li ib qho kev ywj pheej molecule, Adamax tsis muaj cov ntaub ntawv toxicological ywj siab, cov ntaub ntawv tswj hwm, lossis cov ntawv sau npe kho mob hauv cov ntaub ntawv tshawb fawb pej xeem. Nws cov kev tshawb fawb yog feem ntau raws li extrapolations los ntawm cov ntaub ntawv scientific ntawm Semax tsev neeg; yog li ntawd, cov kev txwv hauv qab no yuav tsum tau to taub raws li kev soj ntsuam inferential raws li cov txheej txheem kev tshawb fawb uas twb muaj lawm.
Contraindication Scenario 1: Kev Tshawb Fawb Txog Kev Mob Siab thiab Kev Mob Siab
Adamax tsis pom zoo siv rau hauv cov qauv ntawm kev ntxhov siab loj, kev ntxhov siab, lossis kev puas siab puas ntsws bipolar.
Raws li cov ntaub ntawv pov thawj uas twb muaj lawm, cov tshuaj uas muaj nyob hauv tib chav kawm adamantane derivative xws li Adamax (xws li amantadine) qhia meej meej rau cov neeg mob uas muaj kev puas siab puas ntsws, mob hlwb hnyav, lossis keeb kwm ntawm qaug dab peg. Tej yam tshwm sim ntawm Adamax tau hais nyob rau hauv cov neeg siv kev soj ntsuam cov ntaub ntawv muaj xws li kev ntxhov siab vim, hyperexcitability, mus ob peb vas instability, thiab pw tsaug zog cuam tshuam; Cov teebmeem no yuav qhia txog qhov tsis paub txog qhov txawv txav hauv cov qauv kab mob neuropsychiatric.
Yog tias lub hom phiaj kev tshawb fawb suav nrog kev soj ntsuam ntxaws ntxaws ntawm kev tswj hwm lub siab lossis tus cwj pwm ntxhov siab, kev cuam tshuam nrog dopaminergic- txhim kho cov teebmeem tuaj yeem npog lossis ua rau tsis meej pem cov kev coj cwj pwm no, ua rau cov ntaub ntawv raug tsim los ua tsis tau.
Contraindication Scenario 2: Cardiovascular Function thiab Hemodynamics Research
Adamax tsis pom zoo siv rau hauv kev tshawb fawb ntawm cov qauv kab mob plawv xws li ntshav siab, arrhythmias, lossis myocardial ischemia.
Paub cov teebmeem pharmacological ntawm adamantane suav nrog cov teebmeem hauv plawv (siab ntshav siab, palpitations), thiab nws tau pom zoo kom siv nrog ceev faj rau cov neeg mob uas muaj keeb kwm ntawm cov kab mob cerebrovascular, congestive plawv tsis ua hauj lwm, los yog peripheral edema. Txawm hais tias qhov tshwj xeeb ntawm cov hlab plawv kev nyab xeeb ntawm adamantane tsis tau raug ntsuas los ntawm kev siv cov tshuaj toxicology, cov tshuaj tiv thaiv tsis zoo ntawm nws cov qauv analogues qhia tias muaj peev xwm tawm ntawm - cov phiaj xwm txaus ntshai.
Kev nthuav qhia cov tebchaw uas tuaj yeem cuam tshuam cov ntshav siab thiab lub plawv dhia mus rau hauv cov qauv kev tshawb fawb uas xav tau lub hauv paus ruaj khov hemodynamic tuaj yeem ua rau muaj kev cuam tshuam loj heev hauv kev txhais cov ntaub ntawv thiab yuav qhia txog cov teeb meem kev noj qab haus huv tsiaj uas tsis tau pom dua.
Contraindication Scenario 3: Mob thiab Ntev Neurotoxicity thiab Epilepsy Studies
Adamantane tsis pom zoo rau kev siv hauv kev tshawb fawb txiav txim siab qhov pib mob vwm, lub tswv yim ntawm qaug dab peg, lossis ntsuas qhov kev puas tsuaj neurotoxic.
Adamantane compounds tuaj yeem ua rau muaj kev qaug dab peg ntau zaus, thiab cov koob tshuaj ntau tau ua rau qaug dab peg hauv kev tshawb fawb tsiaj. Adamantane yog sau rau siv nrog ceev faj rau cov neeg mob uas muaj keeb kwm ntawm qaug dab peg. Txhua qhov kev cuam tshuam uas tuaj yeem txo qis qhov qaug dab peg yuav ua rau muaj kev cuam tshuam tsis sib xws hauv cov qauv kev qaug dab peg lossis qaug dab peg, ua rau cov qauv tshwm sim los ntawm cov txheej txheem pathophysiological tiag tiag. Thaum siv rau kev txheeb xyuas cov ntsiab lus neurotoxic, qhov cuam tshuam ncaj qha cuam tshuam rau kev tshawb fawb siv tau ntawm koob tshuaj - teb kev sib raug zoo.
Contraindication Scenario 4: Reproductive Development thiab Perinatal Studies
Adamax tsis pom zoo siv rau hauv kev tshawb fawb ntawm cov tsiaj cev xeeb tub, kev loj hlob ntawm embryonic, kev cuam tshuam lactation, lossis tus cwj pwm ntawm cov xeeb ntxwv.
Tsiaj kev tshawb fawb ntawm adamantane thiab nws cov derivatives tau pom tias 50 mg / kg ib hnub twg hauv cov nas (kwv yees li 12 npaug ntawm tib neeg koob tshuaj) yog embryotoxic thiab teratogenic, thiab tawm hauv cov kua mis. Txawm hais tias cov ntaub ntawv toxicity ntawm kev yug me nyuam rau adamax nws tus kheej tsis muaj, nws yuav tsum raug suav hais tias yog ib yam khoom tsis zoo uas muaj peev xwm txaus ntshai vim tias nws nyob hauv tib chav kawm tshuaj.
Kev nthuav qhia cov ntsiab lus tshiab yam tsis muaj kev ntsuam xyuas kev nyab xeeb ntawm kev yug me nyuam hauv kev tshawb fawb perinatal tuaj yeem qhia txog qhov tsis sib haum xeeb uas tsis tuaj yeem tswj tau thiab ua txhaum txoj cai thoob ntiaj teb lees paub rau cov tsiaj kuaj.
Contraindication Scenario 5: Mechanism of Action Attribution Studies as a Semax Alternative
Adamax tsis pom zoo los ua ib qho kev hloov pauv ncaj qha rau Semax hauv kev tshawb fawb txog kev ua haujlwm raws li qhov "adamax hloov kho" cov nyhuv.
"Adamax" tsis muaj kev tshaj tawm rau pej xeem, txheeb xyuas nws tus kheej, thiab zoo -txoj kev txhais cov ntsiab lus hauv cov ntaub ntawv tshawb fawb tseem ceeb. Cov kev tshawb fawb sib piv nrog Semax feem ntau yog ua raws li kev xav ntau dua li qhov tseeb qhov sib xws, thiab ntau qhov chaw piav qhia txog qhov cuam tshuam ntawm Adamax tiag tiag hais txog Semax cov kev tshawb fawb-** kev faib pawg tsis muaj pov thawj sib thooj.**
Thaum siv hauv kev tshawb fawb txog kev siv tshuab, tsis muaj kev ywj pheej loj spectrometry thiab siab -kev ua tau zoo ntawm cov kua chromatography validation, ib qho kev txiav txim siab hais txog "dab tsi tshwj xeeb qhov kev hloov kho adamantane confers" tsis muaj qhov tsim nyog kev pom zoo.
Contraindication Scenario Six: Kev Kawm Yuav Tsum Tau Ua Raws Li Txoj Cai
Adamax tsis pom zoo siv rau hauv ib qho kev tshawb fawb uas xav tau FDA, EMA, lossis MHRA kev pom zoo.
Txhua txoj kev tshawb fawb txog tib neeg lossis ua tus neeg sib tw tshuaj yuav tsum pib nrog GMP-cov ntaub ntawv ua raws li cov ntaub ntawv raw, ib qhov dej-txhais lus tsis huv, thiab cov kev tshawb fawb txog tshuaj toxicology (mob, rov ua dua- koob tshuaj, genotoxicity, kev ua me nyuam toxicity, carcinogenicity assessment). Adamax tsis suav nrog hauv cov hierarchy no. Nrog rau nws hauv kev tshuaj ntsuam xyuas tshuaj lossis kev tshawb fawb txog kev ua raws cai preclinical tsis ua raws li cov qauv kev cai thiab tsis tuaj yeem dhau qhov kev tshuaj xyuas cov neeg sib tw rau cov yam ntxwv ntawm cov khoom.
Contraindication Scenario Xya: Ntev -Tsev Kawm Ntawv Kev Nyab Xeeb lossis Tolerability Studies
Adamax tsis pom zoo siv rau hauv cov kev tshawb fawb soj ntsuam cov txiaj ntsig sib txuas, kev txhim kho kev kam rau siab, lossis kev tawm tsam tawm tom qab ntev - kev tswj hwm lub sijhawm.
Adamax tau piav qhia tias yog ib yam khoom uas tuaj yeem tsim kev kam rau siab nrog kev siv txuas ntxiv, thiab nws cov ntaub ntawv kev nyab xeeb ntev - lub sij hawm tsis muaj tag nrho. Yog tsis muaj cov ntaub ntawv tshuaj pharmacokinetic (ib nrab- lub neej, kev faib cov ntaub so ntswg, txoj hauv kev tshem tawm) thiab rov ua dua - koob tshuaj toxicology, ib qho kev cuam tshuam ntawm lub sijhawm ntev - yuav ntsib qhov tsis muaj pov thawj tseem ceeb.